Association Between Traditional Herbal Diet and Nasopharyngeal Carcinoma Risk: A Prospective Cohort Study in Southern China.
Association Between Traditional Herbal Diet and Nasopharyngeal Carcinoma Risk: A Prospective Cohort Study in Southern China.
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传统草药饮食与鼻咽癌风险之间的关联：中国南方的一项前瞻性队列研究
DOI：
10.3389/fonc.2021.715242
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发表时间：
2021
影响因子：
4.7
通讯作者：
Lin AH
中科院分区：
文献类型：
--
作者：
Lyu YH;Lin CY;Xie SH;Li T;Liu Q;Ling W;Lu YQ;Cao SM;Lin AH
草药饮食与鼻咽癌(NPC)的发展缺乏前瞻性的证据。因此，我们在中国南部的一项前瞻性队列研究中评估了凉汤和凉茶与鼻咽癌的相关性。基于2008年至2015年建立的鼻咽癌筛查队列，收集了中国南部四会市10179名年龄在30-69岁之间的人的草药饮食消费、潜在混杂因素和EB病毒抗体水平的信息。用COX回归模型检验草药饮食与鼻咽癌风险的关系，用Logistic回归模型检验草药饮食与EBV再激活的关系。在平均7.54年的随访期间，69名参与者患上了鼻咽癌。饮用草药汤与鼻咽癌风险降低相关，最高摄入频率的HR值为0.31(95%可信区间：0.15-0.62)，持续时间较长的HR值为0.29(95%可信区间：0.16-0.51)。然而，草药茶与此并无显著关联。此外，在基线的所有参与者中，我们发现草药汤与EBV血清阳性呈负相关，EB病毒衣壳抗原免疫球蛋白A抗体(VCA-IgA)和核抗原-1(EBNA1-IgA)的调整OR值分别为0.78(95%CI：0.65~0.93)和0.76(95%CI：0.64~0.91)和0.70(95%CI：0.59~0.84)；在非鼻咽癌患者中也观察到了相反的关联。在植物抑制EB病毒再激活的情况下，草药汤可显著降低流行区鼻咽癌的风险。
Prospective evidence for herbal diet and nasopharyngeal carcinoma (NPC) development is absent. We therefore evaluated the associations of herbal soup and herbal tea with NPC in a prospective cohort study in southern China. Based on an NPC screening cohort established in 2008–2015, information on herbal diet consumption, potential confounding factors, and Epstein-Barr virus (EBV) antibody levels were collected from 10,179 individuals aged 30–69 years in Sihui city, southern China. Cox regression models were performed to examine herbal diet with NPC risk, and logistic regression models were used to examine herbal diet with EBV reactivation. During a median of 7.54 years of follow-up, 69 participants developed NPC. Herbal soup consumption was associated with decreased NPC risk, with HRs of 0.31 (95% confidence interval (CI): 0.15–0.62) for the highest intake frequency and 0.29 (95% CI: 0.16–0.51) for a longer duration. However, herbal tea was not significantly associated. Moreover, we identified herbal soup was inversely associated with EBV seropositivity among all the participants at baseline, with the adjusted ORs being 0.78 (95% CI: 0.65–0.93) for immunoglobulin A antibodies against EBV capsid antigens (VCA-IgA) and 0.76 (95% CI: 0.64–0.91) for nuclear antigen 1 (EBNA1-IgA) in those with the highest frequency and 0.70 (95% CI: 0.59–0.84) for VCA-IgA and 0.64 (95% CI: 0.54–0.77) for EBNA1-IgA in those with the longer duration. Inverse associations were also observed in non-NPC individuals. With inhibition of EBV reactivation by plants, herbal soup could significantly decrease the risk of NPC in endemic areas.
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DOI：
10.1155/2014/985176
发表时间：
2014
期刊：
Evidence-based complementary and alternative medicine : eCAM
影响因子：
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作者：
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