Hormonal Determinants of Growth and Weight Gain in the Human Fetus and Preterm Infant.

Hormonal Determinants of Growth and Weight Gain in the Human Fetus and Preterm Infant.
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DOI:
10.3390/nu15184041
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发表时间:
2023-09-18
期刊:
影响因子:
5.9
通讯作者:
Freemark M
Freemark M
中科院分区:
医学2区
文献类型:
--
作者:
Page L;Younge N;Freemark M

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控制人类胎儿和新生儿线性生长和体重增加的因素知之甚少。我们在这里审查的变化,线性增长,体重增加,瘦体重,和脂肪量在中期和晚期妊娠和产后早期的背景下,在母体,胎盘,胎儿和新生儿的激素,生长因子和脂肪细胞因子的分泌和行动的变化。我们评估了激素决定因素对胎盘营养输送的影响,以及早产对激素表达和出生后生长及代谢功能的影响。然后,我们讨论了各种产妇疾病和营养和药物干预对胎儿和围产期激素和生长因子的生产,生长和脂肪沉积的影响,并考虑在该领域的重要悬而未决的问题。
The factors controlling linear growth and weight gain in the human fetus and newborn infant are poorly understood. We review here the changes in linear growth, weight gain, lean body mass, and fat mass during mid- and late gestation and the early postnatal period in the context of changes in the secretion and action of maternal, placental, fetal, and neonatal hormones, growth factors, and adipocytokines. We assess the effects of hormonal determinants on placental nutrient delivery and the impact of preterm delivery on hormone expression and postnatal growth and metabolic function. We then discuss the effects of various maternal disorders and nutritional and pharmacologic interventions on fetal and perinatal hormone and growth factor production, growth, and fat deposition and consider important unresolved questions in the field.
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