The Association between Newborn Regional Body Composition and Cord Blood Concentrations of C-Peptide and Insulin-Like Growth Factor I.
The Association between Newborn Regional Body Composition and Cord Blood Concentrations of C-Peptide and Insulin-Like Growth Factor I.
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DOI：
10.1371/journal.pone.0121350
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发表时间：
2015
期刊：
影响因子：
3.7
通讯作者：
Pryds O
中科院分区：
文献类型：
--
作者：
Carlsen EM;Renault KM;Jensen RB;Nørgaard K;Jensen JE;Nilas L;Cortes D;Michaelsen KF;Pryds O
妊娠晚期胎儿生长受c肽和胰岛素样生长因子I （IGF-I）的部分调控。产前暴露，包括母亲肥胖和妊娠期体重增加以及出生体重高，与随后的代谢疾病有关。我们评估了新生儿区域身体组成与脐带血c肽和IGF-I水平之间的关系。我们前瞻性地纳入了肥胖和正常体重的母亲及其新生儿；采集脐带血并冷冻。招募完成后，同时进行c肽和igf - 1的分析。在出生48小时内用双能x线吸收仪扫描（DXA）评估新生儿局部身体组成。336名足月婴儿有资格参加这项研究；其中174名（52%）婴儿采集了脐带血。总脂肪量、腹部脂肪量、手臂和腿部脂肪量与c肽呈正相关（p < 0.001）。手臂和腿部脂肪量与IGF-I浓度相关：每增加一倍IGF-I 28 g[95%可信区间：4.53]。总脂肪量或腹部脂肪量与igf - 1之间没有关联。无脂质量与c肽（p < 0.001）和IGF-I （p = 0.004）呈正相关。外周脂肪组织积累与脐带血c肽和IGF-I相关。总脂肪和腹部脂肪块与c肽有关，而与IGF-I无关。因此，新生儿肥胖部分通过c肽介导，早期线性生长与igf - 1有关。
Third trimester fetal growth is partially regulated by C-peptide and insulin-like growth factor I (IGF-I). Prenatal exposures including maternal obesity and high gestational weight gain as well as high birth weight have been linked to subsequent metabolic disease. We evaluated the associations between newborn regional body composition and cord blood levels of C-peptide and IGF-I. We prospectively included obese and normal-weight mothers and their newborns; cord blood was collected and frozen. Analyses of C-peptide and IGF-I were performed simultaneously, after recruitment was completed. Newborn regional body composition was assessed with dual-energy X-ray absorptiometry scanning (DXA) within 48 hours of birth. Three hundred thirty-six term infants were eligible to participate in the study; of whom 174 (52%) infants had cord blood taken. Total, abdominal and arm and leg fat mass were positively associated with C-peptide (p < 0.001). Arm and leg fat mass was associated with IGF-I concentration: 28 g [95% confidence interval: 4, 53] per doubling of IGF-I. There was no association between total or abdominal fat mass and IGF-I. Fat-free mass was positively associated with both C-peptide (p < 0.001) and IGF-I (p = 0.004). Peripheral fat tissue accumulation was associated with cord blood C-peptide and IGF-I. Total and abdominal fat masses were related to C-peptide but not to IGF-I. Thus, newborn adiposity is partially mediated through C-peptide and early linear growth is associated with IGF-I.
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DOI：
10.3945/ajcn.2009.29128
发表时间：
2010-06
期刊：
The American journal of clinical nutrition
影响因子：
--
作者：
Crozier SR;Inskip HM;Godfrey KM;Cooper C;Harvey NC;Cole ZA;Robinson SM;Southampton Women's Survey Study Group
通讯作者：
Southampton Women's Survey Study Group
影响因子：
5.8
作者：
Ibanez, Lourdes;Sebastiani, Giorgia;de Zegher, Francis
通讯作者：
de Zegher, Francis
DOI：
10.1016/s0002-9378(03)00828-7
发表时间：
2003-12-01
影响因子：
9.8
作者：
Catalano, PM;Thomas, A;Amini, SB
通讯作者：
Amini, SB
影响因子：
8.3
作者：
Gaillard, Romy;Steegers, Eric A. P.;Jaddoe, Vincent W. V.
通讯作者：
Jaddoe, Vincent W. V.
影响因子：
7.7
作者：
HAPO Study Cooperative Research Group
通讯作者：
HAPO Study Cooperative Research Group