A model for cortical rewiring following deafferentation and focal stroke.
A model for cortical rewiring following deafferentation and focal stroke.
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DOI：
10.3389/neuro.10.010.2009
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发表时间：
2009
影响因子：
3.2
通讯作者：
Wörgötter F
中科院分区：
文献类型：
--
作者：
Butz M;van Ooyen A;Wörgötter F
目前尚不清楚突触重新布线的结构可塑性在多大程度上是损伤后皮质重新映射的原因。最近的双光子激光成像研究表明，突触重新布线在成人大脑中持续存在，并且在大脑损伤或感觉输入丧失（皮质传入神经阻滞）后急剧增加。我们使用循环神经网络模型来研究外周病变后突触重新布线的时间过程。为此，我们代表皮质神经元的轴突和树突元件来模拟突触形成、修剪和突触重新布线。神经元以活性依赖性方式增加和减少轴突和树突元件的数量，以维持其活性处于稳态平衡。在这项研究中，我们证明突触重新布线有助于正常发育以及随后病变期间的神经元稳态。我们表明，处于稳态的网络（因此可以被视为成人网络）补偿输入损失的能力要小得多。有趣的是，我们发现暂停刺激网络比持续刺激更能有效地促进重组。这可以解释为神经元快速适应这种刺激，而暂停可以防止正刺激效果的饱和。这些发现可能会提出改善神经康复治疗的策略。
It is still unclear to what extent structural plasticity in terms of synaptic rewiring is the cause for cortical remapping after a lesion. Recent two-photon laser imaging studies demonstrate that synaptic rewiring is persistent in the adult brain and is dramatically increased following brain lesions or after a loss of sensory input (cortical deafferentation). We use a recurrent neural network model to study the time course of synaptic rewiring following a peripheral lesion. For this, we represent axonal and dendritic elements of cortical neurons to model synapse formation, pruning and synaptic rewiring. Neurons increase and decrease the number of axonal and dendritic elements in an activity-dependent fashion in order to maintain their activity in a homeostatic equilibrium. In this study we demonstrate that synaptic rewiring contributes to neuronal homeostasis during normal development as well as following lesions. We show that networks in homeostasis, which can therefore be considered as adult networks, are much less able to compensate for a loss of input. Interestingly, we found that paused stimulation of the networks are much more effective promoting reorganization than continuous stimulation. This can be explained as neurons quickly adapt to this stimulation whereas pauses prevents a saturation of the positive stimulation effect. These findings may suggest strategies for improving therapies in neurologic rehabilitation.
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影响因子：
64.8
作者：
Engert, F;Bonhoeffer, T
通讯作者：
Bonhoeffer, T
影响因子：
25
作者：
Fischer, M;Kaech, S;Matus, A
通讯作者：
Matus, A
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3.3
作者：
Butz, M;Teuchert-Noodt, G
通讯作者：
Teuchert-Noodt, G
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1.9
作者：
DAMMASCH, IE;WAGNER, GP;WOLFF, JR
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16.2
作者：
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通讯作者：
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