The dynamic kidney matrisome - is the circadian clock in control?
The dynamic kidney matrisome - is the circadian clock in control?
复制标题
动态的肾脏基质体——生物钟在控制之中吗？
DOI：
10.1016/j.matbio.2022.05.005
复制
发表时间：
2022
期刊：
影响因子：
--
通讯作者：
Preston R
中科院分区：
文献类型：
--
作者：
Preston R
哺乳动物的生物钟网络负责协调许多生理过程，这些生理过程是稳态所必需的。外周组织表现出昼夜节律性，并且核心时钟组分的功能障碍已经涉及以异常细胞外基质为特征的疾病的发病机制，所述异常细胞外基质例如纤维化（太多的无序基质）和组织分解（太少的基质）。肾脏疾病的特征是蛋白尿，其沿着滤过率，表现出强烈的昼夜节律振荡。临床观察和小鼠研究表明，存在24小时肾脏时钟，负责肾功能的昼夜节律振荡。最近的实验证据还表明，细胞-基质相互作用和细胞外基质的生物力学性质在调节外周生物钟中起关键作用，并且这种机制似乎是细胞和组织类型特异性的。因此，建立一个时间分辨的肾脏基质体可以提供一个有用的工具，用于研究细胞外基质和细胞内的时间保持机制之间的双向相互作用，在这个关键的生态位组织。这篇综述总结了最新的遗传和生化证据，将肾脏生理和疾病与昼夜节律系统联系起来，特别关注细胞外基质。我们还回顾了解剖昼夜节律通路在特定组织中的作用所需的实验方法和方法，并概述了昼夜节律生物学的转化方面，包括昼夜节律医学如何用于治疗肾脏疾病。
The circadian clock network in mammals is responsible for the temporal coordination of numerous physiological processes that are necessary for homeostasis. Peripheral tissues demonstrate circadian rhythmicity and dysfunction of core clock components has been implicated in the pathogenesis of diseases that are characterized by abnormal extracellular matrix, such as fibrosis (too much disorganized matrix) and tissue breakdown (too little matrix). Kidney disease is characterized by proteinuria, which along with the rate of filtration, displays robust circadian oscillation. Clinical observation and mouse studies suggest the presence of 24 h kidney clocks responsible for circadian oscillation in kidney function. Recent experimental evidence has also revealed that cell-matrix interactions and the biomechanical properties of extracellular matrix have key roles in regulating peripheral circadian clocks and this mechanism appears to be cell- and tissue-type specific. Thus, establishing a temporally resolved kidney matrisome may provide a useful tool for studying the two-way interactions between the extracellular matrix and the intracellular time-keeping mechanisms in this critical niche tissue. This review summarizes the latest genetic and biochemical evidence linking kidney physiology and disease to the circadian system with a particular focus on the extracellular matrix. We also review the experimental approaches and methodologies required to dissect the roles of circadian pathways in specific tissues and outline the translational aspects of circadian biology, including how circadian medicine could be used for the treatment of kidney disease.
登录
查看更多内容
DOI：
10.4161/cc.9.6.11046
发表时间：
2010-03-15
期刊：
Cell cycle (Georgetown, Tex.)
影响因子：
--
作者：
Gery S;Koeffler HP
通讯作者：
Koeffler HP
影响因子：
--
作者：
Gossan, Nicole;Zeef, Leo;Hensman, James;Hughes, Alun;Bateman, John F.;Rowley, Lynn;Little, Christopher B.;Piggins, Hugh D.;Rattray, Magnus;Boot-Handford, Raymond P.;Meng, Qing-Jun
通讯作者：
Meng, Qing-Jun
年龄依赖性肾小球基底膜增厚对肾小球水力传导率没有重大影响。
DOI：
10.1093/ndt/gfh067
发表时间：
2004
期刊：
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association
影响因子：
--
作者：
K. Neumann;C. Kellner;K. Kühn;H. Stolte;H. Schurek
通讯作者：
H. Schurek
影响因子：
15.9
作者：
Sever, Sanja;Altintas, Mehmet M.;Reiser, Jochen
通讯作者：
Reiser, Jochen
正常活动日尿中微生物蛋白和N-乙酰-β-D-氨基葡萄糖苷酶（NAG）排泄量的昼夜变化[J].
DOI：
--
发表时间：
1990
期刊：
Nihon Jinzo Gakkai shi
影响因子：
--
作者：
M. Suzuki;S. Ikawa
通讯作者：
S. Ikawa