Role of serum immunoglobulins for predicting sarcoidosis outcome: A cohort study.
Role of serum immunoglobulins for predicting sarcoidosis outcome: A cohort study.
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DOI：
10.1371/journal.pone.0193122
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发表时间：
2018
期刊：
影响因子：
3.7
通讯作者：
Jégo P
中科院分区：
文献类型：
--
作者：
Belhomme N;Jouneau S;Bouzillé G;Decaux O;Lederlin M;Guillot S;Perlat A;Jégo P
结节病是一种全身性肉芽肿性疾病，其结局多种多样。血清蛋白电泳是一种容易获得的常规诊断检查，以寻找高丙种球蛋白血症，这是常见的，并排除其他肉芽肿性疾病，如常见的变异性免疫缺陷。我们的目的是评估基线免疫球蛋白水平对结节病预后的影响。我们在雷恩大学医院进行了一项回顾性队列研究，其中纳入了2006年至2014年期间在基线时进行血清蛋白电泳的所有新诊断患者。主要结局是诊断后2年内需要皮质类固醇治疗，次要结局是治疗患者复发的发生率。80例患者纳入研究，其中41.25%表现出球蛋白率升高。在单变量分析中，ACE水平升高>70 U/l、非洲-加勒比血统和肺外受累与皮质类固醇治疗的需要相关。在多变量分析中，只有ACE升高（OR = 1.03，IC95% 1.01-1.05，p = 0.009）和肺外受累（OR = 5.8，IC95% 1.4-24，p = 0.015）具有显著性。免疫球蛋白水平与主要结局无关。关于次要结局，在随访两年的34例治疗患者中，没有一项研究特征可预测复发。诊断时的免疫球蛋白水平与结节病的演变无关。升高的ACE水平和存在初始肺外受累均与需要皮质类固醇治疗的更严重的病程相关。
Sarcoidosis is a systemic granulomatous disease which carries variable outcomes. Serum protein electrophoresis is an easily accessible and routinely performed examination at diagnosis, in order to search for hypergammaglobulinemia, which is frequently found, and to rule out other granulomatous diseases such as common variable immunodeficiency. We aimed to assess the impact of baseline immunoglobulin level on the outcome of sarcoidosis. We conducted a retrospective cohort-study, at Rennes University Hospital, in which all newly diagnosed patients for whom a serum protein electrophoresis had been performed at baseline were enrolled, from 2006 to 2014. The main outcome was the need for corticosteroid treatment within 2 years from diagnosis, the secondary outcome was the occurrence of relapse among treated patients. Eighty patients were included in the study, and 41.25% of them exhibited an elevated globulins rate. In univariate analysis, an elevated ACE level >70 U/l, Afro-Caribbean origin, and extra-pulmonary involvement, were associated with the need for corticosteroid treatment. In multivariate analysis, only ACE elevation (OR = 1.03, IC95% 1.01–1.05, p = 0.009) and extra-pulmonary involvement (OR = 5.8, IC95% 1.4–24, p = 0.015) were significant. Immunoglobulin level was not associated with the main outcome. Regarding the secondary outcome, none of the studied features were predictive of relapse among the 34 treated patients followed for two years. There was no relation between the immunoglobulin level at diagnosis and the evolution of sarcoidosis. An elevated ACE level and the presence of initial extra-pulmonary involvement were both associated with a more severe course of the disease necessitating a corticosteroid treatment.
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影响因子：
9.1
作者：
Bargagli, Elena;Bennett, David;Rottoli, Paola
通讯作者：
Rottoli, Paola
DOI：
10.1111/j.1749-6632.1986.tb18537.x
发表时间：
1986-06-06
影响因子：
5.2
作者：
ISRAEL, HL;KARLIN, P;DELISSER, OG
通讯作者：
DELISSER, OG
影响因子：
9.6
作者：
Gottlieb, JE;Israel, HL;Patrick, H
通讯作者：
Patrick, H
影响因子：
10
作者：
SCHOENFELD, N;SCHMOLKE, B;LODDENKEMPER, R
通讯作者：
LODDENKEMPER, R
DOI：
10.1164/ajrccm.164.10.2104046
发表时间：
2001-11-15
影响因子：
24.7
作者：
Baughman, RP;Teirstein, AS;Cherniak, R
通讯作者：
Cherniak, R