Challenges for the Newborn Following Influenza Virus Infection and Prospects for an Effective Vaccine.
Challenges for the Newborn Following Influenza Virus Infection and Prospects for an Effective Vaccine.
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DOI：
10.3389/fimmu.2020.568651
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发表时间：
2020
影响因子：
7.3
通讯作者：
Alexander-Miller MA
中科院分区：
文献类型：
--
作者：
Alexander-Miller MA
新生儿感染流感病毒后患严重疾病的风险显著增加。这是他们幼稚的状态、免疫反应性改变以及缺乏对这些个人有效的疫苗共同造成的结果。许多研究表明，新生儿免疫系统的先天和适应性手臂都存在缺陷。这些改变的结果是抗体和T细胞反应的数量和质量上的下降。这篇综述总结了新生儿在建立有效的反应以清除流感病毒和限制感染后疾病方面的障碍。此外，还讨论了开发能够在这些高危人群中引起保护性反应的疫苗的挑战和机会。
Newborns are at significantly increased risk of severe disease following infection with influenza virus. This is the collective result of their naïve status, altered immune responsiveness, and the lack of a vaccine that is effective in these individuals. Numerous studies have revealed impairments in both the innate and adaptive arms of the immune system of newborns. The consequence of these alterations is a quantitative and qualitative decrease in both antibody and T cell responses. This review summarizes the hurdles newborns experience in mounting an effective response that can clear influenza virus and limit disease following infection. In addition, the challenges, as well as the opportunities, for developing vaccines that can elicit protective responses in these at risk individuals are discussed.
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影响因子：
17.1
作者：
Andrews SF;Huang Y;Kaur K;Popova LI;Ho IY;Pauli NT;Henry Dunand CJ;Taylor WM;Lim S;Huang M;Qu X;Lee JH;Salgado-Ferrer M;Krammer F;Palese P;Wrammert J;Ahmed R;Wilson PC
通讯作者：
Wilson PC
影响因子：
5.5
作者：
Gans, H;DeHovitz, R;Arvin, AM
通讯作者：
Arvin, AM
影响因子：
5.8
作者：
Crowe, James E Jr;Williams, John V
通讯作者：
Williams, John V
影响因子：
8
作者：
Clemens, Elene;Angeletti, Davide;Alexander-Miller, Martha A.
通讯作者：
Alexander-Miller, Martha A.
影响因子：
5.9
作者：
Cobey S;Hensley SE
通讯作者：
Hensley SE