Spatiotemporal parameters for energy efficient kilohertz-frequency nerve block with low onset response.
Spatiotemporal parameters for energy efficient kilohertz-frequency nerve block with low onset response.
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DOI：
10.1186/s12984-023-01195-8
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发表时间：
2023-06-05
影响因子：
5.1
通讯作者：
Grill, Warren M.
中科院分区：
文献类型：
--
作者：
Pena, Edgar;Pelot, Nicole A.;Grill, Warren M.
电神经传导阻滞通过可逆性和局部失活躯体神经和自主神经，在治疗疾病方面具有巨大的潜力。然而，相对较高的能量需求和在用于阻塞的千赫兹频率(KHF)信号开始时存在不必要的激励，给有效的平移带来了障碍。频率、电极几何形状和波形形状是已知的影响阻断阈值和起搏反应的因素，但现有数据对如何选择这些参数以优化神经阻滞的理解有限。我们评估了KHF神经阻滞剂对大鼠胫神经的跨频率(5-60 GHz)、电极几何形状(单极、双极和三极)和波形形状。我们提出了一种新的基于傅里叶变换的复合信号构造方法，系统地对KHF波形设计空间进行采样。在测试的频率中，能够阻断的最低频率(5-16千赫)不是最节能的。此外，双极袖口需要最大的电流和功率才能阻断，单极袖口需要最小的电流，三极和单极袖口都需要最低的功率。TRIPOLAR袖带在不同频率之间产生的起效反应最小。由基频(F0)的一次谐波和2f0的二次谐波叠加而成的复合信号与单独的正弦信号相比，可以在较低的阈值和较低的起始响应下被阻断。这种效应强烈地依赖于二次谐波的相位以及一次和二次谐波的相对幅度。这种效应还依赖于电极的几何形状：单极和三极袖带在大多数实验中显示出明显的复合信号效应；双极袖带在大多数实验中没有明显的信号效应。我们的数据提供了关于阻断阈值和在可以阻断的频率边界处的起始响应的新信息。我们的结果还显示了空间参数(袖带几何形状)和时间参数(频率和波形形状)之间的交互作用。最后，虽然以前的研究表明，时间参数可能会降低起搏反应，但只有通过增加阻断阈值(反之亦然)，我们的结果表明，波形对KHF反应的影响可以用来降低能量和起搏反应。网上版载有补充材料，可在10.1186/s12984-023-01195-8查阅。
Electrical nerve conduction block has great potential for treatment of disease through reversible and local inactivation of somatic and autonomic nerves. However, the relatively high energy requirements and the presence of undesired excitation at the onset of the kilohertz-frequency (KHF) signals used for block pose obstacles to effective translation. Frequency, electrode geometry, and waveform shape are known to influence block threshold and onset response, but available data provide a limited understanding of how to select these parameters to optimize nerve block. We evaluated KHF nerve block in rat tibial nerve across frequencies (5–60 kHz), electrode geometries (monopolar, bipolar, and tripolar), and waveform shapes. We present a novel Fourier-based method for constructing composite signals that systematically sample the KHF waveform design space. The lowest frequencies capable of blocking (5–16 kHz) were not the most energy-efficient among the tested frequencies. Further, bipolar cuffs required the largest current and power to block, monopolar cuffs required the lowest current, and both tripolar and monopolar cuffs required the lowest power. Tripolar cuffs produced the smallest onset response across frequencies. Composite signals comprised of a first harmonic sinusoid at fundamental frequency (f0) superposed on a second harmonic sinusoid at 2f0 could block at lower threshold and lower onset response compared to the constituent sinusoids alone. This effect was strongly dependent on the phase of the second harmonic and on the relative amplitudes of the first and second harmonics. This effect was also dependent on electrode geometry: monopolar and tripolar cuffs showed clear composite signal effects in most experiments; bipolar cuffs showed no clear effects in most experiments. Our data provide novel information about block threshold and onset response at the boundary of frequencies that can block. Our results also show an interaction between spatial (cuff geometry) and temporal (frequency and waveform shape) parameters. Finally, while previous studies suggested that temporal parameters could reduce onset response only in exchange for increased block threshold (or vice versa), our results show that waveform shape influences KHF response in ways that can be exploited to reduce both energy and onset responses. The online version contains supplementary material available at 10.1186/s12984-023-01195-8.
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影响因子：
3
作者：
Franke, Manfred;Bhadra, Niloy;Bhadra, Narendra;Kilgore, Kevin
通讯作者：
Kilgore, Kevin
影响因子：
--
作者：
Green, David B;Kilgore, Joseph A;Bender, Shane A;Daniels, Robert J;Gunzler, Douglas D;Vrabec, Tina L;Bhadra, Niloy
通讯作者：
Bhadra, Niloy
影响因子：
3.4
作者：
Bhadra, N;Kilgore, KL
通讯作者：
Kilgore, KL
影响因子：
4
作者：
Pelot NA;Behrend CE;Grill WM
通讯作者：
Grill WM
神经袖带电极几何形状对高频神经传导阻滞中起始反应放电的影响。
DOI：
10.1109/tnsre.2010.2071882
发表时间：
2010-12
期刊：
IEEE transactions on neural systems and rehabilitation engineering : a publication of the IEEE Engineering in Medicine and Biology Society
影响因子：
--
作者：
Ackermann DM Jr;Bhadra N;Foldes EL;Wang XF;Kilgore KL
通讯作者：
Kilgore KL