A longitudinal pilot proton MRS investigation of the manic and euthymic states of bipolar disorder.
A longitudinal pilot proton MRS investigation of the manic and euthymic states of bipolar disorder.
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DOI：
10.1038/tp.2012.84
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发表时间：
2012-09-11
影响因子：
6.8
通讯作者：
Öngür D
中科院分区：
文献类型：
--
作者：
Brady RO Jr;Cooper A;Jensen JE;Tandon N;Cohen B;Renshaw P;Keshavan M;Öngür D
有几条证据表明，大脑能量产生功能障碍是双相情感障碍的一个关键组成部分。特别是，在这种情况下观察到的脑乳酸水平升高表明，从有氧代谢转变为无氧代谢，这可能是线粒体异常的结果。大多数先前对大脑代谢物的成像研究都是在情绪良好或抑郁的双相情感患者中进行的，或者比较了处于不同情绪状态的不同人群。我们试图测量相同患者在躁狂状态和心境良好状态下的脑代谢产物浓度。鉴于双相情感障碍患者临床状态的戏剧性变化，我们假设之前观察到的双相情感障碍患者乳酸浓度的异常可能表现出状态依赖性的变化。本研究对15例双相情感障碍患者(平均年龄36.1岁)在急性躁狂住院期间进行了前扣带回皮质和顶枕皮质的质子磁共振波谱检查(平均青年躁狂量表(YMRS)22.1分)。这些受试者中有7人返回(平均间隔21.16个月)，在欣快期(平均YMRS 2.0)进行重复成像。一组年龄和性别匹配的对照组参与者(N=6)也进行了扫描。我们报告，在躁狂期间，双相情感障碍受试者的乳酸水平与健康对照受试者相当，但在欣快期这些水平显著降低。其他代谢物没有明显变化。这些结果表明，在双相情感障碍的生物学过程中，能量代谢的变化与情绪有关。此外，这一发现有可能被用作评估新疗法以及澄清情绪障碍之间的诊断的生物标记物。
Several lines of evidence implicate dysfunction in brain energy production as a key component of bipolar disorder. In particular, elevated brain lactate levels observed in this condition suggest a shift from aerobic to anaerobic metabolism, possibly as a result of mitochondrial abnormalities. Most prior imaging studies of brain metabolites were performed in either euthymic or depressed bipolar patients or compared different populations in different mood states. We sought to measure brain metabolite concentrations in the same patients in both manic and euthymic states. Given the dramatic changes in clinical state of bipolar disorder patients, we hypothesized that previously observed abnormalities in lactate concentrations in bipolar disorder might show state dependent changes. In this study 15 patients (mean age 36.1 years) diagnosed with bipolar I disorder underwent proton magnetic resonance spectroscopy of the anterior cingulate cortex and parieto-occipital cortex during hospitalization for acute mania (mean Young Mania Rating Scale (YMRS) 22.1). Seven of these subjects returned (mean interval 21.16 months) to have imaging repeated while euthymic (mean YMRS 2.0). A group of age- and gender-matched control participants (N=6) were scanned as well. We report that during mania, bipolar disorder subjects had lactate levels comparable to healthy control subjects but during euthymia these levels were significantly reduced. No significant change was observed for other metabolites. These results implicate mood dependent alterations in energy metabolism in the biology of bipolar disorder. Additionally, this finding has potential use as a biomarker for both evaluating novel treatments as well as diagnostic clarification between mood disorders.
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影响因子：
2.9
作者：
Jensen, J. Eric;Licata, Stephanie C.;Renshaw, Perry F.
通讯作者：
Renshaw, Perry F.
最初因单相抑郁症住院的患者患双相情感障碍的风险
影响因子：
17.7
作者：
Goldberg, JF;Harrow, M;Whiteside, JE
通讯作者：
Whiteside, JE
影响因子：
6.6
作者：
KATO, T;TAKAHASHI, S;INUBUSHI, T
通讯作者：
INUBUSHI, T
影响因子：
5.4
作者：
Joffe, RT;MacQueen, GM;Young, LT
通讯作者：
Young, LT
影响因子：
6
作者：
Cataldo, Anne M.;McPhie, Donna L.;Cohen, Bruce M.
通讯作者：
Cohen, Bruce M.