Head and neck cancer risk factors in the French West Indies.
Head and neck cancer risk factors in the French West Indies.
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DOI：
10.1186/s12885-021-08787-4
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发表时间：
2021-09-30
期刊：
影响因子：
3.8
通讯作者：
Luce D
中科院分区：
文献类型：
--
作者：
Auguste A;Joachim C;Deloumeaux J;Gaete S;Michineau L;Herrmann-Storck C;Duflo S;Luce D
法属西印度群岛 (FWI) 的头颈鳞状细胞癌 (HNSCC) 发病率相对较高，尽管吸烟和饮酒的患病率较低。人们对 FWI 的其他危险因素知之甚少。我们评估了几个因素与 HNSCC 风险之间的关联、FWI 中的人群归因分数 (PAF)，并按亚位点、性别和年龄对这些 PAF 进行了比较。我们进行了一项基于人群的病例对照研究（145 例病例和 405 例对照）。我们使用逻辑回归模型来估计调整后的比值比 (OR)、PAF 及其 95% 置信区间 (CI)。吸烟、饮酒、高危HPV、HNC家族史、低BMI以及多种职业和行业与HNSCC的发生显着相关。大多数 HNSCC 病例可归因于吸烟（65.7%）和饮酒（44.3%）。烟草和/或酒精综合消费的 PAF 为 78.2%，男性 (85%) 远高于女性 (33%)。其余危险因素的 PAF 为：HNSCC 家族史为 9%，低 BMI 为 9%，高危 HPV 为 15%，职业为 25%。所有危险因素的总 PAF 为 89.0% (95% CI = 82.0–93.2)。按性别划分的合并 PAF 男性 (93.4%, 95% CI = 87.5–96.5) 显着高于女性 (56.4%, 95% CI = 18.7–76.6)。在所研究的危险因素中，烟草和酒精似乎对 HNSCC 发病率影响最大，尤其是男性。 FWI 的 HNSCC 预防计划应针对戒烟和戒酒，特别是男性。未来的研究应强调职业因素的作用，以更好地了解这种疾病。在线版本包含可在 10.1186/s12885-021-08787-4 获取的补充材料。
The incidence of head and neck squamous cell carcinoma (HNSCC) in the French West Indies (FWI) is relatively high, despite a low prevalence of tobacco smoking and alcohol drinking. Little is known about other risk factors in the FWI. We assessed associations between several factors and HNSCC risk, their population attributable fractions (PAF) in the FWI, and compared these PAFs by subsite, sex and age. We conducted a population-based case-control study (145 cases and 405 controls). We used logistic regression models to estimate adjusted odds-ratios (OR), PAFs and their 95% confidence intervals (CI). Tobacco smoking, alcohol drinking, high-risk HPV, family history of HNC, low BMI and several occupations and industries were significantly associated to the occurrence of HNSCC. The majority of HNSCC cases were attributable to tobacco smoking (65.7%) and alcohol (44.3%). The PAF for the combined consumption of tobacco and/or alcohol was 78.2% and was considerably larger in men (85%) than in women (33%). The PAFs for the remaining risk factors were 9% for family history of HNSCC, 9% for low BMI, 15% for high-risk HPV, and 25% for occupations. The overall PAF for all risk factors combined was 89.0% (95% CI = 82.0–93.2). The combined PAFs by sex were significantly greater in men (93.4%, 95% CI = 87.5–96.5) than in women (56.4%, 95% CI = 18.7–76.6). Tobacco and alcohol appeared to have the greatest impact on HNSCC incidence among the studied risk factors, especially among men. Prevention programs for HNSCC in the FWI should target tobacco and alcohol cessation, particularly in men. Future research should emphasise on the role of occupational factors to better understand this disease. The online version contains supplementary material available at 10.1186/s12885-021-08787-4.
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影响因子：
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