Antioxidant activity and phenolic compounds of 112 traditional Chinese medicinal plants associated with anticancer.
Antioxidant activity and phenolic compounds of 112 traditional Chinese medicinal plants associated with anticancer.
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DOI：
10.1016/j.lfs.2003.09.047
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发表时间：
2004-03-12
期刊：
影响因子：
6.1
通讯作者：
Corke H
中科院分区：
文献类型：
--
作者：
Cai Y;Luo Q;Sun M;Corke H
使用传统中药预防和治疗癌症已引起越来越多的关注。对50科112种中草药抗氧化活性及酚类化合物进行了研究。采用改进的ABTS·+法系统评价了各提取物的总抗氧化能力（Trolox equivalent antioxidant capacity，TEAC）。草药甲醇提取物的TEAC值和总酚含量分别为46.7至17，323 μmol Trolox当量/100 g干重（DW）和0.22至50.3 g没食子酸当量/100 g DW。抗氧化活性与总酚含量呈显著正线性关系（R2值均≥0.95），表明酚类化合物是供试中草药的主要抗氧化成分。初步鉴定和分析了大部分供试药材中的主要酚类化合物，主要包括酚酸类、黄酮类、鞣质类、香豆素类、木脂素类、醌类、二苯乙烯类和姜黄素类。这些草药表现出更强的抗氧化活性，并含有显着高于普通蔬菜和水果的酚类物质。与抗癌相关的传统中草药植物可能是潜在的天然抗氧化剂和有益的化学预防剂的来源。
Cancer prevention and treatment using traditional Chinese medicines have attracted increasing interest. This study characterizes antioxidant activity and phenolic compounds of traditional Chinese medicinal plants associated with anticancer, comprising 112 species from 50 plant families. The improved ABTS•+ method was used to systematically assess the total antioxidant capacity (Trolox equivalent antioxidant capacity, TEAC) of the medicinal extracts. The TEAC values and total phenolic content for methanolic extracts of herbs ranged from 46.7 to 17,323 μmol Trolox equivalent/100 g dry weight (DW), and from 0.22 to 50.3 g of gallic acid equivalent/100 g DW, respectively. A positive, significant linear relationship between antioxidant activity and total phenolic content (all R2 values≥0.95) showed that phenolic compounds were the dominant antioxidant components in the tested medicinal herbs. Major types of phenolic compounds from most of the tested herbs were preliminarily identified and analyzed, and mainly included phenolic acids, flavonoids, tannins, coumarins, lignans, quinones, stilbenes, and curcuminoids. These medicinal herbs exhibited far stronger antioxidant activity and contained significantly higher levels of phenolics than common vegetables and fruits. Traditional Chinese medicinal plants associated with anticancer might be potential sources of potent natural antioxidants and beneficial chemopreventive agents.
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影响因子：
6.1
作者：
Liu, M;Li, XQ;Liu, RH
通讯作者：
Liu, RH
影响因子：
6.1
作者：
HAGERMAN, AE;BUTLER, LG
通讯作者：
BUTLER, LG
影响因子：
6.1
作者：
Cai, YZ;Sun, M;Corke, H
通讯作者：
Corke, H
DOI：
10.1016/s1383-5718(98)00130-2
发表时间：
1998-11-09
影响因子：
1.9
作者：
Kaur, S;Grover, IS;Kaur, S
通讯作者：
Kaur, S
影响因子：
6.1
作者：
Mau, JL;Lin, HC;Chen, CC
通讯作者：
Chen, CC