Syngeneic leukocytes together with suramin failed to improve immunodeficiency in a case of transfusion-associated AIDS after syngeneic bone marrow transplantation.

Syngeneic leukocytes together with suramin failed to improve immunodeficiency in a case of transfusion-associated AIDS after syngeneic bone marrow transplantation.
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在同基因骨髓移植后,同基因白细胞与苏拉明一起未能改善输血相关艾滋病病例的免疫缺陷。

DOI:
10.1182/blood.v71.3.666.bloodjournal713666
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发表时间:
1988
期刊:
影响因子:
20.3
通讯作者:
BJ Bast
BJ Bast
中科院分区:
医学1区
文献类型:
--
作者:
L. Verdonck;GC de Gast;JM Lange;HJ Schuurman;AW Dekker;BJ Bast

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一名22岁的男子接受了同基因骨髓移植(BMT)治疗急性淋巴细胞性白血病,通过输血感染了人类免疫缺陷病毒(HIV)。移植后早期表现为急性脑病合并免疫性血小板减少,移植后20个月出现获得性免疫缺陷综合征(AIDS)。由于他有一位同基因捐赠者,通过反复转移健康的同基因淋巴细胞,并将反复转移的同基因淋巴细胞与抗病毒药物苏拉明相结合,以保护输入的白细胞免受艾滋病毒的攻击,研究了重建免疫系统的可能性。通过这些努力,临床上或患者的免疫功能没有观察到改善。
A 22-year-old man who underwent syngeneic bone marrow transplantation (BMT) for acute lymphoblastic leukemia acquired a human immunodeficiency virus (HIV) infection by transfusion of blood products from a donor at risk. The manifestations were acute encephalopathy together with immune thrombocytopenia in the early posttransplant period, and acquired immunodeficiency syndrome (AIDS) developed 20 months after BMT. Because he had a syngeneic donor, the possibility of reconstituting the immune system was investigated by repeated transfer of healthy syngeneic lymphocytes and by combining repeated transfer of syngeneic lymphocytes with the antiviral agent suramin to protect the infused leukocytes from being attacked by HIV. No improvement was observed clinically or in the patient's immune functions by these efforts.
患有免疫性血小板减少症的同性恋男性的目标血小板抗原。
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发表时间: 1985
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