Syngeneic leukocytes together with suramin failed to improve immunodeficiency in a case of transfusion-associated AIDS after syngeneic bone marrow transplantation.
Syngeneic leukocytes together with suramin failed to improve immunodeficiency in a case of transfusion-associated AIDS after syngeneic bone marrow transplantation.
复制标题
在同基因骨髓移植后,同基因白细胞与苏拉明一起未能改善输血相关艾滋病病例的免疫缺陷。
DOI:
10.1182/blood.v71.3.666.bloodjournal713666
复制
发表时间:
1988
期刊:
影响因子:
20.3
通讯作者:
BJ Bast
中科院分区:
文献类型:
--
作者:
L. Verdonck;GC de Gast;JM Lange;HJ Schuurman;AW Dekker;BJ Bast
A 22-year-old man who underwent syngeneic bone marrow transplantation (BMT) for acute lymphoblastic leukemia acquired a human immunodeficiency virus (HIV) infection by transfusion of blood products from a donor at risk. The manifestations were acute encephalopathy together with immune thrombocytopenia in the early posttransplant period, and acquired immunodeficiency syndrome (AIDS) developed 20 months after BMT. Because he had a syngeneic donor, the possibility of reconstituting the immune system was investigated by repeated transfer of healthy syngeneic lymphocytes and by combining repeated transfer of syngeneic lymphocytes with the antiviral agent suramin to protect the infused leukocytes from being attacked by HIV. No improvement was observed clinically or in the patient's immune functions by these efforts.
登录
查看更多内容
DOI:
10.1056/nejm198511283132202
发表时间:
1985
期刊:
The New England journal of medicine
影响因子:
--
作者:
Stricker,RB;Abrams,DI;Corash,L;Shuman,MA
通讯作者:
Shuman,MA
影响因子:
3.6
作者:
Witherspoon,RP;Lum,LG;Storb,R
通讯作者:
Storb,R
DOI:
10.1056/nejm198404053101404
发表时间:
1984
期刊:
The New England journal of medicine
影响因子:
--
作者:
Murray,HW;Rubin,BY;Masur,H;Roberts,RB
通讯作者:
Roberts,RB
DOI:
10.1056/nejm198305193082001
发表时间:
1983
期刊:
The New England journal of medicine
影响因子:
--
作者:
Harris,C;Small,CB;Klein,RS;Friedland,GH;Moll,B;Emeson,EE;Spigland,I;Steigbigel,NH
通讯作者:
Steigbigel,NH