Thermally-actuated microfluidic membrane valve for point-of-care applications.
Thermally-actuated microfluidic membrane valve for point-of-care applications.
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DOI：
10.1038/s41378-021-00260-3
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发表时间：
2021
影响因子：
7.9
通讯作者：
Rowlands CJ
中科院分区：
文献类型：
--
作者：
Sesen M;Rowlands CJ
微流体技术使得低容量的生物化学反应能够在护理点进行。微流体中的一个关键部件是微流体阀。微流体阀不仅可用于在交叉点处引导流动，而且还允许实时调节混合物/稀释液，甚至提供蠕动泵送能力。在从实验室芯片到芯片实验室的过渡中，必须确保微流体阀的设计需要较少的外围设备，并且它们是可运输的。介绍了一种热驱动微流控阀。阀门本身是用现成的组件制造的，不需要复杂的洁净室技术。它表明，可以通过电源和Arduino微控制器控制和操作多个阀门;这是朝着能够在护理点进行分析测定的可运输微流体设备迈出的重要一步。据计算，单个致动器的成本低于1美元，这突出了所提出的阀的扩展潜力。通过调节具有Y形连接通道几何形状的连续流动微流体芯片中的水/染料混合物的比率来证明阀操作。操作一个微流体阀所需的功率已经在理论上和实验上表征。瓣膜的循环操作已被证明为65小时，585次致动。所提出的阀能够驱动500 μm × 50 μm的矩形微流体通道，预期温度升高高达5 °C。实现的最快致动时间为阀门关闭（加热）2 s和阀门打开（冷却）9 s。
Microfluidics has enabled low volume biochemistry reactions to be carried out at the point-of-care. A key component in microfluidics is the microfluidic valve. Microfluidic valves are not only useful for directing flow at intersections but also allow mixtures/dilutions to be tuned real-time and even provide peristaltic pumping capabilities. In the transition from chip-in-a-lab to lab-on-a-chip, it is essential to ensure that microfluidic valves are designed to require less peripheral equipment and that they are transportable. In this paper, a thermally-actuated microfluidic valve is presented. The valve itself is fabricated with off-the-shelf components without the need for sophisticated cleanroom techniques. It is shown that multiple valves can be controlled and operated via a power supply and an Arduino microcontroller; an important step towards transportable microfluidic devices capable of carrying out analytical assays at the point-of-care. It is been calculated that a single actuator costs less than $1, this highlights the potential of the presented valve for scaling out. The valve operation is demonstrated by adjusting the ratio of a water/dye mixture in a continuous flow microfluidic chip with Y-junction channel geometry. The power required to operate one microfluidic valve has been characterised both theoretically and experimentally. Cyclical operation of the valve has been demonstrated for 65 h with 585 actuations. The presented valve is capable of actuating rectangular microfluidic channels of 500 μm × 50 μm with an expected temperature increase of up to 5 °C. The fastest actuation times achieved were 2 s for valve closing (heating) and 9 s for valve opening (cooling).
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