Anatomical connectivity patterns predict face selectivity in the fusiform gyrus.

Anatomical connectivity patterns predict face selectivity in the fusiform gyrus.
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DOI:
10.1038/nn.3001
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发表时间:
2011-12-25
影响因子:
25
通讯作者:
--
中科院分区:
医学1区
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神经科学中的一个基本假设是,大脑结构决定功能。因此,皮质的不同功能区域与其他区域的连接在结构上应该是不同的。我们测试了这一假说与梭状回面部选择性的关系。通过仅使用通过扩散加权成像测量的结构连接性,我们能够预测梭形回中面部的功能激活。这些预测的表现超过了两个控制模型和一个标准的群体平均基准。从这些参与者身上发现的结构-功能关系在预测第二组参与者的激活方面非常可靠,尽管获取参数和刺激存在差异。因此,这种方法可以可靠地估计不能执行功能成像任务的参与者的激活,并且是组激活图的替代方案。此外,我们确定了大脑皮质区域,其连通性对预测梭形体内的面部选择性有很大影响,这表明人类面部加工可能存在一种机械结构。
A fundamental assumption in neuroscience is that brain structure determines function. Accordingly, functionally distinct regions of cortex should be structurally distinct in their connections to other areas. We tested this hypothesis in relation to face selectivity in the fusiform gyrus. By using only structural connectivity, as measured through diffusion weighted imaging, we are able to predict functional activation to faces in the fusiform gyrus. These predictions outperformed two control models and a standard group-average benchmark. The structure-function relationship discovered from these participants was highly robust in predicting activation in a second group of participants, despite differences in acquisition parameters and stimuli. This approach can thus reliably estimate activation in participants who cannot perform functional imaging tasks, and is an alternative to group-activation maps. Additionally, we identified cortical regions whose connectivity is highly influential in predicting face-selectivity within the fusiform, suggesting a possible mechanistic architecture underlying face processing in humans.
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