A functional role of meningeal lymphatics in sex difference of stress susceptibility in mice.
A functional role of meningeal lymphatics in sex difference of stress susceptibility in mice.
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脑膜淋巴管在小鼠应激敏感性性别差异中的功能作用
DOI：
10.1038/s41467-022-32556-x
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发表时间：
2022-08-16
影响因子：
16.6
通讯作者：
中科院分区：
文献类型：
--
作者：
重度抑郁症是最常见的心理健康状况之一。脑膜淋巴管对于将脑脊液中的分子引流到外周免疫系统至关重要。它们在抑郁样行为中的潜在作用尚未研究。在这里，我们在小鼠中显示，亚慢性可变压力作为抑郁样行为的模型损害女性而不是男性的脑膜炎。操纵脑膜神经调节小鼠对压力诱导的抑郁和焦虑样行为的易感性的性别差异，以及内侧前额叶皮层和腹侧被盖区的改变，这些脑区对情绪调节至关重要。总之，我们的研究结果表明，脑膜淋巴损伤有助于小鼠对应激的易感性，并且脑膜淋巴损伤的恢复可能具有调节抑郁样行为的潜力。压力反应的性别差异背后的机制尚不清楚。在这里，作者表明脑膜炎功能障碍调节小鼠对抑郁和焦虑样行为的应激易感性的性别差异。
Major depressive disorder is one of the most common mental health conditions. Meningeal lymphatics are essential for drainage of molecules in the cerebrospinal fluid to the peripheral immune system. Their potential role in depression-like behaviour has not been investigated. Here, we show in mice, sub-chronic variable stress as a model of depression-like behaviour impairs meningeal lymphatics in females but not in males. Manipulations of meningeal lymphatics regulate the sex difference in the susceptibility to stress-induced depression- and anxiety-like behaviors in mice, as well as alterations of the medial prefrontal cortex and the ventral tegmental area, brain regions critical for emotional regulation. Together, our findings suggest meningeal lymphatic impairment contributes to susceptibility to stress in mice, and that restoration of the meningeal lymphatics might have potential for modulation of depression-like behaviour. The mechanisms underlying sex differences in response to stress are unclear. Here, the authors show that meningeal lymphatics dysfunction modulates the sex difference in the stress susceptibility to depression- and anxiety-like behaviours in mice.
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