Light regulation of secondary metabolism in fungi.
Light regulation of secondary metabolism in fungi.
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DOI：
10.1186/s13036-023-00374-4
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发表时间：
2023-08-31
影响因子：
5.6
通讯作者：
He, Bin
中科院分区：
文献类型：
--
作者：
Yu, Wenbin;Pei, Rongqiang;Zhang, Yufei;Tu, Yayi;He, Bin
真菌进化出独特的代谢调节机制以适应不断变化的环境。真菌适应的关键特征之一是产生次级代谢产物（SM），这是生存所必需的，对生物体有益。这些SM中的许多是响应于环境线索（例如光）而产生的。在所有研究的真菌物种中，天鹅绒复合物转录因子VeA是光调控网络的中心参与者。除了生长和发育外，光的强度和波长也会影响多种次生代谢产物的形成。最近的研究（主要针对曲霉属物种）表明，VeA-VelB和LaeA的二聚体不仅调节响应光的基因表达，而且还可以参与调节SM的产生。此外，复合物对不同类型的次级代谢产物具有广泛的调节作用。本文综述了光在真菌次生代谢调控中的作用。此外，我们综述了光受体，转录因子和信号通路参与光依赖性调节的次生代谢。讨论了转录因子对次生代谢产物产生的影响，以及光调节在药物和其他产品生产中的潜在应用。最后，我们提供了一个概述，目前在这一领域的研究，并提出了未来的研究潜力。
Fungi have evolved unique metabolic regulation mechanisms for adapting to the changing environments. One of the key features of fungal adaptation is the production of secondary metabolites (SMs), which are essential for survival and beneficial to the organism. Many of these SMs are produced in response to the environmental cues, such as light. In all fungal species studied, the Velvet complex transcription factor VeA is a central player of the light regulatory network. In addition to growth and development, the intensity and wavelength of light affects the formation of a broad range of secondary metabolites. Recent studies, mainly on species of the genus Aspergillus, revealed that the dimer of VeA-VelB and LaeA does not only regulate gene expression in response to light, but can also be involved in regulating production of SMs. Furthermore, the complexes have a wide regulatory effect on different types of secondary metabolites. In this review, we discussed the role of light in the regulation of fungal secondary metabolism. In addition, we reviewed the photoreceptors, transcription factors, and signaling pathways that are involved in light-dependent regulation of secondary metabolism. The effects of transcription factors on the production of secondary metabolites, as well as the potential applications of light regulation for the production of pharmaceuticals and other products were discussed. Finally, we provided an overview of the current research in this field and suggested potential areas for future research.
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