Hypoglossal nerve injury with long nerve resection leading to slow motoneuron death
Hypoglossal nerve injury with long nerve resection leading to slow motoneuron death
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长神经切除导致舌下神经损伤导致缓慢运动神经元死亡
DOI：
10.1016/j.neulet.2019.134668
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发表时间：
2020
影响因子：
2.5
通讯作者：
Moriizumi T
中科院分区：
文献类型：
--
作者：
Fukushima N;Kobayashi T;Kakegawa A;Sumitomo N;Nagira A;Moriizumi T
成年动物的外周神经挤压损伤被认为不会引发逆行性神经元细胞死亡;然而，几项研究报告了严重损伤（包括神经横断、切除或撕脱）后的神经元细胞死亡。然而，神经元细胞死亡率在不同研究中有所不同。在这项研究中，我们评估了非常严重的神经损伤长神经切除成年大鼠的结果。暴露右侧舌下神经（XII），切除9 mm节段。在切除后4、8和12周，从头侧到尾侧切片计数XII神经元的数量。与未损伤的左侧相比，损伤右侧的XII神经元的数量在XII神经切除后减少。术后4、8、12周神经元存活率分别为83.5%、73.9%、61.1%，明显低于对照组。广泛的XII神经切除后的XII神经元的数量在相对长的时间内逐渐下降，揭示了广泛的神经切除导致损伤神经元的缓慢细胞死亡。
Crush injury to peripheral nerves in adult animals is considered not to trigger retrograde neuronal cell death; however, several studies reported neuronal cell death following severe injuries including nerve transection, resection, or avulsion. However, the rate of neuronal cell death varied among studies. In this study, we evaluated the outcomes of very severe nerve injury by long nerve resection in adult rats. Right hypoglossal (XII) nerve was exposed, and a 9-mm section was resected. At 4, 8, and 12 weeks after the resection, the number of XII neurons were counted in from the rostral to caudal sections. The number of XII neurons in the injured right side was reduced after the XII nerve resection compared with the uninjured left side. The mean rates of surviving neurons at 4, 8, and 12 weeks after the nerve resection were 83.5 %, 73.9 %, and 61.1 %, respectively, which were significantly lower than those of the control. The number of XII neurons after extensive XII nerve resection declined gradually over a relatively long time period, revealing that extensive nerve resection led to slow cell death of the injured neurons.
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DOI：
--
发表时间：
2006
期刊：
Int J Dev Neurosci 24
影响因子：
--
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Fujita K;Yokouchi K;Fukuyama T;Fukushima N;Kawagishi K;Moriizumi T
通讯作者：
Moriizumi T