Depriving Mice of Sleep also Deprives of Food.
Depriving Mice of Sleep also Deprives of Food.
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剥夺老鼠的睡眠也剥夺了食物。
DOI：
10.3390/clockssleep4010006
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发表时间：
2022-02-11
期刊：
影响因子：
3.1
通讯作者：
Franken P
中科院分区：
文献类型：
--
作者：
Đukanović N;La Spada F;Emmenegger Y;Niederhäuser G;Preitner F;Franken P
睡眠-觉醒行为和昼夜节律都与能量代谢和食物摄入密切相关。众所周知，老鼠进食时间的改变会影响大脑和肝脏中的生物钟基因节奏，睡眠不足的人往往会吃得更多，体重增加。先前对小鼠的观察表明，睡眠剥夺（SD）改变了生物钟基因的表达，因此可能与食物摄入量的改变有关，而不是睡眠本身的丧失。然而，SD是否会影响小鼠的食物摄入量以及这可能如何影响时钟基因的表达尚不清楚。因此，我们定量（i）在6小时SD期间获得食物或不获得食物的小鼠中时钟基因Per 1，Per 2，Dbp和Cry 1的皮质表达，以及（ii）基线，SD和恢复睡眠期间的食物摄入。我们发现，食物剥夺并没有改变SD引起的大脑皮层时钟基因的变化。此外，我们发现，尽管SD期间的食物摄入量与基线没有差异，但小鼠在随后的恢复期间体重减轻并增加食物摄入量。我们的结论是，SD与食物匮乏，由此产生的能量不足可能有助于SD的影响，通常被解释为对睡眠不足的反应。
Both sleep-wake behavior and circadian rhythms are tightly coupled to energy metabolism and food intake. Altered feeding times in mice are known to entrain clock gene rhythms in the brain and liver, and sleep-deprived humans tend to eat more and gain weight. Previous observations in mice showing that sleep deprivation (SD) changes clock gene expression might thus relate to altered food intake, and not to the loss of sleep per se. Whether SD affects food intake in the mouse and how this might affect clock gene expression is, however, unknown. We therefore quantified (i) the cortical expression of the clock genes Per1, Per2, Dbp, and Cry1 in mice that had access to food or not during a 6 h SD, and (ii) food intake during baseline, SD, and recovery sleep. We found that food deprivation did not modify the SD-incurred clock gene changes in the cortex. Moreover, we discovered that although food intake during SD did not differ from the baseline, mice lost weight and increased food intake during subsequent recovery. We conclude that SD is associated with food deprivation and that the resulting energy deficit might contribute to the effects of SD that are commonly interpreted as a response to sleep loss.
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影响因子：
4.6
作者：
Fang Z;Spaeth AM;Ma N;Zhu S;Hu S;Goel N;Detre JA;Dinges DF;Rao H
通讯作者：
Rao H
DOI：
10.1152/ajpregu.00294.2004
发表时间：
2004-11-01
影响因子：
2.8
作者：
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作者：
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作者：
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通讯作者：
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影响因子：
56.9
作者：
Dudley, CA;Erbel-Sieler, C;McKnight, SL
通讯作者：
McKnight, SL