Altered salience network connectivity predicts macronutrient intake after sleep deprivation.

Altered salience network connectivity predicts macronutrient intake after sleep deprivation.
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DOI:
10.1038/srep08215
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发表时间:
2015-02-03
期刊:
影响因子:
4.6
通讯作者:
Rao H
Rao H
中科院分区:
综合性期刊3区
文献类型:
--
作者:
Fang Z;Spaeth AM;Ma N;Zhu S;Hu S;Goel N;Detre JA;Dinges DF;Rao H

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虽然睡眠不足是暴饮暴食和体重增加的一个公认的风险因素,但睡眠剥夺后热量(特别是脂肪)摄入增加的神经机制仍不清楚。在这里,我们使用静息态功能磁共振成像,并检查了一晚完全睡眠剥夺(TSD)后与大量营养素摄入相关的大脑连接变化。与基线睡眠后的一天相比,健康成年人在TSD后的一天中消耗了更大比例的脂肪卡路里和更低比例的碳水化合物卡路里。受试者在TSD后还表现出从背侧前扣带皮层(dACC)到双侧壳核和双侧前扣带皮层(aINS)的显著性网络中的大脑连接增加。此外,dACC-壳核和dACC-aINS连接与TSD后一天内脂肪增加和碳水化合物摄入减少相关,但与基线睡眠后一天内无关。这些发现提供了一种潜在的神经机制,睡眠不足会导致脂肪摄入量增加。
Although insufficient sleep is a well-recognized risk factor for overeating and weight gain, the neural mechanisms underlying increased caloric (particularly fat) intake after sleep deprivation remain unclear. Here we used resting-state functional magnetic resonance imaging and examined brain connectivity changes associated with macronutrient intake after one night of total sleep deprivation (TSD). Compared to the day following baseline sleep, healthy adults consumed a greater percentage of calories from fat and a lower percentage of calories from carbohydrates during the day following TSD. Subjects also exhibited increased brain connectivity in the salience network from the dorsal anterior cingulate cortex (dACC) to bilateral putamen and bilateral anterior insula (aINS) after TSD. Moreover, dACC-putamen and dACC-aINS connectivity correlated with increased fat and decreased carbohydrate intake during the day following TSD, but not during the day following baseline sleep. These findings provide a potential neural mechanism by which sleep loss leads to increased fat intake.
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