Hypo- and hyper-perfusion in MCI and AD identified by different ASL MRI sequences.
Hypo- and hyper-perfusion in MCI and AD identified by different ASL MRI sequences.
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DOI：
10.1007/s11682-023-00764-8
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发表时间：
2023-06
影响因子：
3.2
通讯作者：
Wang, Ze
中科院分区：
文献类型：
--
作者：
Camargo, Aldo;Wang, Ze
动脉自旋标记（ASL）灌注MRI已越来越多地用于阿尔茨海默病（AD）的研究。由于ASL MRI序列在动脉血信号准备和数据采集策略方面差异很大，导致信噪比（SNR）差异很大，因此比较几种广泛使用的ASL MRI序列对ASL测量的脑血流量（CBF）检测AD连续体组间差异的灵敏度具有重要意义。为此，本研究比较了AD研究中的三种ASL MRI序列，包括2D脉冲ASL（PASL）、3D背景抑制（BS）PASL和3D BS伪连续ASL（PCASL）。我们使用的数据来自100名健康和认知正常的老年对照（NC）受试者，75名轻度认知障碍（MCI）患者和57名来自AD神经影像学倡议（ADNI）的阿尔茨海默病（AD）受试者。检查了横截面灌注差异和灌注与临床评估的相关性。主要调查结果包括：3D PCASL序列显示患者与对照组的CBF/rCBF差异大于2D PASL和3D PCASL; MCI显示CBF减少和CBF再分布;从正常老化到MCI和AD，眶额皮质CBF呈现U形变化模式; 3D PCASL显示rCBF与记忆负相关，而2D PASL显示正相关。
Arterial spin labeling (ASL) perfusion MRI has been increasingly used in Alzheimer’s Disease (AD) research. Because ASL MRI sequences differ greatly in terms of arterial blood signal preparations and data acquisition strategies, both leading to a large difference of signal-to-noise ratio (SNR), it is of great translational importance to compare the several widely used ASL MRI sequences regarding sensitivity of ASL measured cerebral blood flow (CBF) for detecting the between-group difference across the AD continuum. To this end, this study compared three ASL MRI sequences in AD research, including the 2D Pulsed ASL (PASL), 3D Background Suppressed (BS) PASL, and 3D BS Pseudo-Continuous ASL (PCASL). We used data from 100 healthy and cognitively normal elderly control (NC) subjects, 75 patients with mild cognitive impairment (MCI), and 57 Alzheimer’s disease (AD) subjects from the AD neuroimaging initiative (ADNI). Both cross-sectional perfusion difference and perfusion versus clinical assessment correlations were examined. The major findings included: 3D PCASL sequence identified stronger patient versus control CBF/rCBF differences than 2D PASL and 3D PCASL; MCI showed reduced CBF and CBF redistribution; CBF in orbito-frontal cortex presents a U-shape change pattern from normal aging to MCI and to AD; 3D PCASL identified negative rCBF to memory correlation while 2D PASL showed positive correlation.
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影响因子：
4.8
作者：
Detre, John A.;Wang, Jiongjiong;Rao, Hengyi
通讯作者：
Rao, Hengyi
影响因子：
14.5
作者：
Jacobs, Heidi I. L.;Hopkins, David A.;Schmahmann, Jeremy D.
通讯作者：
Schmahmann, Jeremy D.
动脉自旋标记血流MRI：其在阿尔茨海默氏病早期表征中的作用。
DOI：
10.3233/jad-2010-091699
发表时间：
2010
期刊：
Journal of Alzheimer's disease : JAD
影响因子：
--
作者：
Alsop DC;Dai W;Grossman M;Detre JA
通讯作者：
Detre JA
影响因子：
3.3
作者：
Hernandez-Garcia, Luis;Aramendia-Vidaurreta, Veronica;Bolar, Divya S.;Dai, Weiying;Fernandez-Seara, Maria A.;Guo, Jia;Madhuranthakam, Ananth J.;Mutsaerts, Henk;Petr, Jan;Qin, Qin;Schollenberger, Jonas;Suzuki, Yuriko;Taso, Manuel;Thomas, David L.;van Osch, Matthias J. P.;Woods, Joseph;Yan, Lirong;Wang, Ze;Zhao, Li;Zhao, Moss Y.;Okell, Thomas W.
通讯作者：
Okell, Thomas W.
DOI：
10.3233/jad-210116
发表时间：
2021
期刊：
Journal of Alzheimer's disease : JAD
影响因子：
--
作者：
Camargo A;Wang Z;Alzheimer’s Disease Neuroimaging Initiative
通讯作者：
Alzheimer’s Disease Neuroimaging Initiative