Outcomes of Radiotherapy for Osseous Echinococcosis of Meriones meridianus
Outcomes of Radiotherapy for Osseous Echinococcosis of Meriones meridianus
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子午线沙眼骨包虫病放射治疗的疗效
DOI：
10.1155/2020/6457419
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发表时间：
2020-08
影响因子：
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通讯作者：
Zengru Xie
中科院分区：
文献类型：
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作者：
Chao Ma;Xuefeng Luo;Wuluhan Mahan;Yahui Tang;Yun Duan;Rui Mao;Zengru Xie
背景骨囊棘球蚴病是一种严重致残的传染病，目前尚无理想的治疗方法。本研究旨在探讨放射线治疗作为骨质癌性食管炎的辅助或姑息治疗的可行性和预后，并对放射线治疗后骨质癌性食管炎的沙鼠的预后进行研究。方法研究采用三组沙鼠的比较对照组设计，将240只骨质CE沙鼠随机分为对照组、40 Gy/5次组和50 Gy/5次组。对沙土鼠进行不同剂量的放射治疗，观察放射治疗后3个月和6个月对沙土鼠及病灶的影响。采用χ2检验、非配对t检验和单因素方差分析进行统计学分析。结果3组在3个月和6个月时的7项指标，包括死亡沙鼠数、溃疡和感染的病灶数、死亡沙鼠数、蛋白质含量、Ca 2+浓度、病灶最大直径和囊肿湿重，与对照组相比差异有统计学意义（P < 0.05）。50 Gy/5次照射组3个月与6个月之间除死亡沙鼠数、溃疡和感染病灶数外，其余指标均存在显著差异。结论50戈伊放射治疗对沙土鼠骨CE有抑制和治疗作用，放射治疗可能是持续性或复发性骨CE的一种治疗选择。
Background Osseous cyst echinococcosis (CE) is an infectious disease that causes disability and deformity in patients, yet there is still no satisfactory treatment. Focusing on the feasibility and prognosis of radiotherapy as an adjuvant or palliative treatment for osseous CE, this study investigated the outcome of Meriones meridianus with osseous CE after radiotherapy. Methods The study utilized a comparison control group design with three groups of gerbils, and 240 osseous CE gerbils were randomly divided into control, 40Gy/5times, and 50Gy/5times groups. Different doses of radiotherapy were given to the gerbils, and then, the effects of radiotherapy on gerbils and lesions were observed at 3 and 6 months after radiotherapy. Statistical analysis was done using χ2 test, unpaired t-test, and one-way ANOVA. Results Significant changes (P < 0.05) were achieved between the three groups in terms of seven parameters at 3 and 6 months, including the number of dead gerbils and lesion sites with ulceration and infection, number of dead scolices, protein content, Ca2+ concentration, the maximum diameter of lesion site, and wet weight of cysts. Except for the number of dead gerbils and lesion sites with ulceration and infection, all other parameters were observed a big difference between 3 months and 6 months in the 50Gy/5times group. Conclusion Radiotherapy at a dose of 50 Gy has inhibitory and therapeutic effects on osseous CE in gerbils, and radiotherapy could probably be a treatment option for persistent or recurrent osseous CE.
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影响因子：
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作者：
Ahn CS;Kim JG;Han X;Kang I;Kong Y
通讯作者：
Kong Y
手术联合放射治疗治疗脊柱肿瘤：已发表报告的回顾
影响因子：
2.1
作者：
Bian Chong;Chen Nong;Li Xi lei;Zhou Xiao gang;Lin Hong;Jiang Li bo;Liu Wang mi;Chen Qian;Dong Jian
通讯作者：
Dong Jian
影响因子：
4
作者：
A. Siracusano;P. Margutti;F. Delunardo;E. Profumo;R. Riganò;B. Buttari;A. Teggi;E. Ortona
通讯作者：
A. Siracusano;P. Margutti;F. Delunardo;E. Profumo;R. Riganò;B. Buttari;A. Teggi;E. Ortona
DOI：
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发表时间：
2011-06
期刊：
Zhongguo ji sheng chong xue yu ji sheng chong bing za zhi = Chinese journal of parasitology & parasitic diseases
影响因子：
--
作者：
Y. Bao;R. Mao;Hong-zhi Qi;Yue-fen Zhang;Ya-qiong Ni;Zengru Xie;Tursun Aziguli;H. Wen
通讯作者：
Y. Bao;R. Mao;Hong-zhi Qi;Yue-fen Zhang;Ya-qiong Ni;Zengru Xie;Tursun Aziguli;H. Wen
随着囊性棘球菌病的进展，甲状腺棘球菌的免疫蛋白质组谱的变化。
影响因子：
3.2
作者：
Ahn CS;Han X;Bae YA;Ma X;Kim JT;Cai H;Yang HJ;Kang I;Wang H;Kong Y
通讯作者：
Kong Y