Intrinsic determinants of retinal axon collateralization and arborization patterns
Intrinsic determinants of retinal axon collateralization and arborization patterns
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视网膜轴突侧支和树枝化模式的内在决定因素
DOI：
--
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发表时间：
1999
期刊：
影响因子：
--
通讯作者：
D. Frost
中科院分区：
文献类型：
--
作者：
P. Bhide;D. Frost
永久性的，新的视网膜投影的主要丘脑体感（ventrobasal）或听觉（内侧膝状体）核可以产生在成年仓鼠，如果上级丘被消融双侧和体感和听觉丘系轴突被切断单侧的出生之日。我们通过用荧光示踪剂1，1 ′-双十八烷基-3，3，3 ′，3 ′-四甲基吲哚羰花青高氯酸盐标记视网膜轴突来研究这些新投射的发展，以检查内在因素和轴突-靶相互作用在视网膜轴突连接特化中的相对作用。我们的主要发现如下：（1）在出生当天进行手术以产生新的视网膜投射的仓鼠中，投射到腹基底核或内侧膝状体核的视网膜神经节细胞轴突发育为三个形态上不同的阶段，即，延长、侧支化和树枝状化，就像正常仓鼠中投射到背外侧膝状体核（主要丘脑视觉核）的视网膜轴突一样。(2)在这两个ventrobasal和内侧膝状体核的手术仓鼠，在背外侧膝状体核的正常仓鼠，侧支最初形成的视网膜神经节细胞轴突的表面和内部组件的视束和只有从表面组件的侧支形成永久性的预测。(3)在成熟的腹基底核和内侧膝状体核，手术仓鼠的离视网膜轴突终末乔木类似于正常仓鼠的外侧膝状体核中观察到的相同的三个形态类，虽然它们的绝对大小似乎被改变。这些数据表明，无论是表面和内部的视束轴突可以产生丘脑侧支在发展过程中，但只有表面的视束轴突可以永久保留丘脑侧支。此外，相同形态类型的离视网膜轴突似乎有助于正常和手术诱导的视网膜投影。神经学比较杂志411：119-129，1999.© 1999 Wiley利斯公司
Permanent, novel retinal projections to the principal thalamic somatosensory (ventrobasal) or auditory (medial geniculate) nuclei can be produced in adult hamsters if the superior colliculus is ablated bilaterally and the somatosensory and auditory lemniscal axons are transected unilaterally on the day of birth. We studied the development of those novel projections by labeling retinal axons with the fluorescent tracer 1,1′‐dioctadecyl‐3,3,3′,3′‐tetramethylindocarbocyanine perchlorate to examine the relative roles of intrinsic factors and axon‐target interactions in the specification of retinal axon connections. Our principal findings are as follows: (1) In hamsters operated on the day of birth to produce the novel retinal projections, retinal ganglion cell axons projecting to the ventrobasal or medial geniculate nuclei develop in three morphologically distinct stages, i.e., elongation, collateralization, and arborization, as do retinal axons projecting to the dorsal lateral geniculate nucleus, the principal thalamic visual nucleus, in normal hamsters. (2) In both the ventrobasal and medial geniculate nuclei of operated hamsters, as in the dorsal lateral geniculate nucleus of normal hamsters, collateral branches were initially formed by retinal ganglion cell axons in both the superficial and internal components of the optic tract and only collaterals from the superficial component formed permanent projections. (3) The retinofugal axon terminal arbors in the ventrobasal and medial geniculate nuclei of mature, operated hamsters resemble the same three morphologic classes that are observed in the lateral geniculate nucleus of normal hamsters, although their absolute size appears to be altered. These data suggest that both superficial and internal optic tract axons can produce thalamic collaterals during development but that only superficial optic tract axons can permanently retain thalamic collaterals. Furthermore, the same morphologic types of retinofugal axons appear to contribute to normal and surgically induced retinal projections. J. Comp. Neurol. 411:119–129, 1999. © 1999 Wiley‐Liss, Inc.
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皮质轴突的目标选择：在发育中的大脑中建立轴突连接的替代机制。
DOI：
10.1101/sqb.1990.055.01.045
发表时间：
1990
期刊：
Cold Spring Harbor symposia on quantitative biology
影响因子：
--
作者：
O'Leary,DD;Bicknese,AR;DeCarlos,JA;Heffner,CD;Koester,SE;Kutka,LJ;Terashima,T
通讯作者：
Terashima,T
发育中的胼胝体中的瞬时轴突分支。
DOI：
10.1093/cercor/3.6.551
发表时间：
1993
期刊：
Cerebral cortex (New York, N.Y. : 1991)
影响因子：
--
作者：
Kadhim,HJ;Bhide,PG;Frost,DO
通讯作者：
Frost,DO
影响因子：
56.9
作者：
COWAN, WM;FAWCETT, JW;STANFIELD, BB
通讯作者：
STANFIELD, BB
仓鼠视觉通路中的神经遗传梯度。
影响因子：
2.9
作者：
Crossland,WJ
通讯作者：
Crossland,WJ
仓鼠体感皮层神经元的视觉反应，实验诱导视网膜投射到体感丘脑。
DOI：
10.1073/pnas.86.1.357
发表时间：
1989
影响因子：
11.1
作者：
Métin,C;Frost,DO
通讯作者：
Frost,DO