Evaluating the profound effect of gut microbiome on host appetite in pigs
Evaluating the profound effect of gut microbiome on host appetite in pigs
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评估肠道微生物组对猪宿主食欲的深远影响
DOI：
10.1186/s12866-018-1364-8
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发表时间：
2018-12
期刊：
影响因子：
4.2
通讯作者：
Huang Lusheng
中科院分区：
文献类型：
--
作者：
Yang Hui;Yang Ming;Fang Shaoming;Huang Xiaochang;He Maozhang;Ke Shanlin;Gao Jun;Wu Jinyuan;Zhou Yunyan;Fu Hao;Chen Congying;Huang Lusheng
背景越来越多的证据表明肠道菌群在宿主的食欲和摄食行为中起着重要作用。然而，什么样的微生物（S），以及它们如何影响猪的食欲仍然未知。结果在这项研究中，280个商业杜洛克猪饲养在一个测试站的昼夜摄食行为记录，连续一段时间的30-100公斤。本文首先分析了宿主性别和遗传因素对猪平均日采食量的影响，但没有观察到显著的影响。我们发现普雷沃菌为主的肠型比密螺旋体肠型有更高的ADFI。此外，在与ADFI正相关的18个OTU中，有12个被注释为普雷沃氏菌，普雷沃氏菌是共丰度网络中的中心菌。这些结果表明，Prevotella可能是一个关键的细菌类群，增加宿主的饲料摄入量。然而，一些产生短链脂肪酸（SCFAs）和乳酸的细菌（如瘤胃球菌和乳酸杆菌）与ADFI呈负相关。预测功能容量分析表明，高ADFI和低ADFI猪的氨基酸生物合成基因富集程度存在显著差异。结论本研究为肠道菌群对猪食欲和摄食行为的影响提供了重要信息。这将有助于我们在养猪业中通过调节肠道微生物来调节猪的食欲。
BackgroundThere are growing evidences showing that gut microbiota should play an important role in host appetite and feeding behavior. However, what kind of microbe(s) and how they affect porcine appetite remain unknown.ResultsIn this study, 280 commercial Duroc pigs were raised in a testing station with the circadian feeding behavior records for a continuous period of 30–100 kg. We first analyzed the influences of host gender and genetics in porcine average daily feed intake (ADFI), but no significant effect was observed. We found that thePrevotella-predominant enterotype had a higher ADFI than theTreponemaenterotype-like group. Furthermore, 12 out of the 18 OTUs positively associated with the ADFI were annotated toPrevotella, andPrevotellawas the hub bacteria in the co-abundance network. These results suggested thatPrevotellamight be a keystone bacterial taxon for increasing host feed intake. However, some bacteria producing short-chain fatty acids (SCFAs) and lactic acid (e.g.RuminococcaceaeandLactobacillus) showed negative associations with the ADFI. Predicted function capacity analysis showed that the genes for amino acid biosynthesis had significantly different enrichment between pigs with high and low ADFI.ConclusionsThe present study provided important information on the profound effect of gut microbiota on porcine appetite and feeding behavior. This will profit us to regulate porcine appetite through modulating the gut microbiome in the pig industry.
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影响因子：
4.8
作者：
V. Dumoulin;F. Moro;A. Barcelo;T. Dakka;J. Cuber
通讯作者：
V. Dumoulin;F. Moro;A. Barcelo;T. Dakka;J. Cuber
影响因子：
3.7
作者：
Majaneva M;Hyytiäinen K;Varvio SL;Nagai S;Blomster J
通讯作者：
Blomster J
影响因子：
5.2
作者：
Yang H;Huang X;Fang S;He M;Zhao Y;Wu Z;Yang M;Zhang Z;Chen C;Huang L
通讯作者：
Huang L
影响因子：
64.8
作者：
Arumugam, Manimozhiyan;Raes, Jeroen;Pelletier, Eric;Le Paslier, Denis;Yamada, Takuji;Mende, Daniel R.;Fernandes, Gabriel R.;Tap, Julien;Bruls, Thomas;Batto, Jean-Michel;Bertalan, Marcelo;Borruel, Natalia;Casellas, Francesc;Fernandez, Leyden;Gautier, Laurent;Hansen, Torben;Hattori, Masahira;Hayashi, Tetsuya;Kleerebezem, Michiel;Kurokawa, Ken;Leclerc, Marion;Levenez, Florence;Manichanh, Chaysavanh;Nielsen, H. Bjorn;Nielsen, Trine;Pons, Nicolas;Poulain, Julie;Qin, Junjie;Sicheritz-Ponten, Thomas;Tims, Sebastian;Torrents, David;Ugarte, Edgardo;Zoetendal, Erwin G.;Wang, Jun;Guarner, Francisco;Pedersen, Oluf;de Vos, Willem M.;Brunak, Soren;Dore, Joel;Weissenbach, Jean;Ehrlich, S. Dusko;Bork, Peer
通讯作者：
Bork, Peer
影响因子：
15.5
作者：
Fadrosh DW;Ma B;Gajer P;Sengamalay N;Ott S;Brotman RM;Ravel J
通讯作者：
Ravel J