Urinary Metabolites of Polycyclic Aromatic Hydrocarbons and the Association with Lipid Peroxidation: A Biomarker-Based Study between Los Angeles and Beijing.
Urinary Metabolites of Polycyclic Aromatic Hydrocarbons and the Association with Lipid Peroxidation: A Biomarker-Based Study between Los Angeles and Beijing.
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DOI：
10.1021/acs.est.5b04629
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发表时间：
2016-04-05
影响因子：
11.4
通讯作者：
Zhu Y
中科院分区：
文献类型：
--
作者：
Lin Y;Qiu X;Yu N;Yang Q;Araujo JA;Zhu Y
空气污染是中国对人类健康的最大威胁之一。作为空气毒物，多环芳烃（PAH）可能给人群带来重大风险；然而，中国的多环芳烃暴露情况及其对健康的影响尚不完全清楚。 2012年，一个暑期交换项目允许10名学生从洛杉矶前往北京并在那里停留10周。基于该计划，本研究调查了两个城市之间尿中 12 种羟基化多环芳烃 (Σ12OH-PAHs) 和丙二醛 (MDA) 浓度的差异。北京的Σ12OH-PAHs中位浓度（14.1μg·g−1肌酐）显着高于洛杉矶（5.78μg·g−1肌酐），表明北京的暴露水平较高。两个城市之间的均质 OH-PAH（例如 1-/2-OH-NAP）比率发生显着变化 (p < 0.01)，这可能表明接触后新陈代谢可能发生变化。观察到 Σ12OH-PAH 与 MDA 之间存在显着关联 (p < 0.01)，但两个城市之间的关联有所不同。这项研究表明，接触多环芳烃可能与新陈代谢的改变有关，并呼吁未来的研究调查这种可能的改变在多环芳烃接触对健康的影响中所起的作用。
Air pollution is among the top threats to human health in China. As air toxicants, polycyclic aromatic hydrocarbons (PAHs) could bring significant risks to population; however, the exposure to PAHs in China and its health impact are not fully understood. In 2012, a summer exchange program allowed 10 students to travel from Los Angeles to Beijing and stay there for 10 weeks. Based on the program, this study investigated the difference in urinary concentration of 12 hydroxylated-PAHs (Σ12OH-PAHs) and malondialdehyde (MDA) between the two cities. The median concentration of Σ12OH-PAHs in Beijing (14.1 μg g−1 creatinine) was significantly higher than that in Los Angeles (5.78 μg g−1 creatinine), indicating a higher exposure in Beijing. The ratios of homogeneous OH-PAHs (e.g., 1-/2-OH-NAP) changed significantly between the two cities (p < 0.01), which might suggest a potential alteration in metabolism subsequent to exposure. A significant association between Σ12OH-PAHs and MDA (p < 0.01) was observed, with the association varying between the two cities. This study suggests that exposure to PAHs might be linked to metabolism alteration and calls for future studies to investigate the role this possible alteration played in the health effects of PAHs exposure.
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影响因子：
10.4
作者：
Bae S;Pan XC;Kim SY;Park K;Kim YH;Kim H;Hong YC
通讯作者：
Hong YC
DOI：
10.1097/jom.0000000000000111
发表时间：
2014-04
影响因子：
3.2
作者：
Barraza-Villarreal A;Escamilla-Nuñez MC;Schilmann A;Hernandez-Cadena L;Li Z;Romanoff L;Sjödin A;Del Río-Navarro BE;Díaz-Sanchez D;Díaz-Barriga F;Sly P;Romieu I
通讯作者：
Romieu I
影响因子：
10.4
作者：
Armstrong B;Hutchinson E;Unwin J;Fletcher T
通讯作者：
Fletcher T
影响因子：
3.9
作者：
Cho, TM;Rose, RL;Hodgson, E
通讯作者：
Hodgson, E
影响因子：
64.8
作者：
Huang, Ru-Jin;Zhang, Yanlin;Prevot, Andre S. H.
通讯作者：
Prevot, Andre S. H.