Exposures to particulate matter and polycyclic aromatic hydrocarbons and oxidative stress in schoolchildren.
Exposures to particulate matter and polycyclic aromatic hydrocarbons and oxidative stress in schoolchildren.
复制标题
DOI：
10.1289/ehp.0901077
复制
发表时间：
2010-04
影响因子：
10.4
通讯作者：
Hong YC
中科院分区：
文献类型：
--
作者：
Bae S;Pan XC;Kim SY;Park K;Kim YH;Kim H;Hong YC
众所周知，空气污染会导致呼吸系统和心血管疾病的死亡和发病率。氧化应激被认为是这些对健康影响的主要机制之一。本研究旨在分析空气动力学直径为≤10μm(PM10)和≤2.5μm(PM2.5)的颗粒物和多环芳烃对学龄儿童尿丙二醛水平的影响。研究人群包括120名学龄儿童。调查和测量于2007年6月4日至9日在四个城市进行--两个在中国(阿拉善和北京)，两个在韩国(济州和首尔)。在研究期间，我们测量了选定学校每天的PM及其金属成分的环境水平。我们还测量了尿中1-羟基芘(1-OHP)和2-萘酚，以评估PAH暴露，以及丙二醛(MDA)，以评估氧化应激。每天测量一次，连续5天。在调整了个体变量后，我们构建了一个线性混合模型来估计PM和PAH对氧化应激的影响。我们发现，从当天到前两天，尿丙二醛水平随着环境PM浓度的增加而显著增加(p<；0.0001)。尿1-OHP水平也与尿丙二醛水平呈正相关，无论有无PM，在模型中有统计学意义(p<；0.05)。室外PM和尿1-OHP与尿丙二醛水平有协同关系。与PM10(铝、铁、锶、镁、硅、砷、钡、锌、铜和镉)和PM2.5(镁、铁、锶、砷、镉、锌、铝、汞、钡和铜)结合的一些金属也与尿丙二醛水平显著相关。接触PM空气污染和多环芳烃与学龄儿童的氧化应激有关。
Air pollution is known to contribute to respiratory and cardiovascular mortality and morbidity. Oxidative stress has been suggested as one of the main mechanisms for these effects on health. The aim of this study was to analyze the effects of exposure to particulate matter (PM) with aerodynamic diameters ≤ 10 μm (PM10) and ≤ 2.5 μm (PM2.5) and polycyclic aromatic hydrocarbons (PAHs) on urinary malondialdehyde (MDA) levels in schoolchildren. The study population consisted of 120 schoolchildren. The survey and measurements were conducted in four cities—two in China (Ala Shan and Beijing) and two in Korea (Jeju and Seoul)—between 4 and 9 June 2007. We measured daily ambient levels of PM and their metal components at the selected schools during the study period. We also measured urinary 1-hydroxypyrene (1-OHP) and 2-naphthol, to assess PAH exposure, and MDA, to assess oxidative stress. Measurements were conducted once a day for 5 consecutive days. We constructed a linear mixed model after adjusting for individual variables to estimate the effects of PM and PAH on oxidative stress. We found statistically significant increases in urinary MDA levels with ambient PM concentrations from the current day to the 2 previous days (p < 0.0001). Urinary 1-OHP level also showed a positive association with urinary MDA level, which was statistically significant with or without PM in the model (p < 0.05). Outdoor PM and urinary 1-OHP were synergistically associated with urinary MDA levels. Some metals bound to PM10 (aluminum, iron, strontium, magnesium, silicon, arsenic, barium, zinc, copper, and cadmium) and PM2.5 (magnesium, iron, strontium, arsenic, cadmium, zinc, aluminum, mercury, barium, and copper) also had significant associations with urinary MDA level. Exposure to PM air pollution and PAHs was associated with oxidative stress in schoolchildren.
登录
查看更多内容
影响因子：
10.4
作者：
Hong YC;Hwang SS;Kim JH;Lee KH;Lee HJ;Lee KH;Yu SD;Kim DS
通讯作者：
Kim DS
DOI：
10.1007/s004200100239
发表时间：
2001-08-01
影响因子：
3
作者：
Fiala, Z;Vyskocil, A;Emminger, S
通讯作者：
Emminger, S
影响因子：
6.5
作者：
Forsberg, B;Hansson, HC;Järvholm, B
通讯作者：
Järvholm, B
影响因子：
3.4
作者：
MohanKumar, Sheba M. J.;Campbell, Arezoo;Veronesi, Bellina
通讯作者：
Veronesi, Bellina
影响因子：
3.5
作者：
Hong, Yun-Chul;Park, Eun-Young;Ha, Eun-Hee
通讯作者：
Ha, Eun-Hee