Electromechanical wave imaging of biologically and electrically paced canine hearts in vivo.
Electromechanical wave imaging of biologically and electrically paced canine hearts in vivo.
复制标题
DOI：
10.1016/j.ultrasmedbio.2013.08.019
复制
发表时间：
2014-01
影响因子：
2.9
通讯作者：
Konofagou, Elisa E.
中科院分区：
文献类型：
--
作者：
Costet, Alexandre;Provost, Jean;Gambhir, Alok;Bobkov, Yevgeniy;Danilo, Peter, Jr.;Boink, Gerard J. J.;Rosen, Michael R.;Konofagou, Elisa E.
关键词：
基于超声的机电波成像（EWI）可以直接和完全无创地标测体内所有四个心腔中的透壁机电激活。在这项研究中，我们评估了EWI的可重复性和可再现性，以及其定位电子和生物起搏器的能力，首次在闭胸，清醒的狗。在正常窦性心律（NSR）和心室自主性心律发生在心脏阻滞的狗与电子和生物起搏器（分别为ESTA和BPM）在六个清醒的动物获得机电激活。房室结消融后，在犬右心室（RV）心内膜心尖植入BPM（n=4），另外2只犬在左心室（LV）心外膜基底植入BPM（n=2）。EWI是在清醒犬的NSR、BPM和起搏期间经胸进行的，使用2000帧/秒的非聚焦发射序列。NSR时，EW起源于右心房（RA），传播到左心房（LA），并从两个心室的多个来源出现。在右心室舒张期，EW起源于右心室尖部，并向两侧心室传播。在BPM期间，EW起源于LV基底侧壁，随后传播到整个心室。EWI可区分BPM与窦性心律和NSR，并识别不同的起搏起源。等时线比较表明EWI具有良好的重复性和可靠性。因此，这些发现表明EWI可能作为一种简单、无创和直接的成像技术，用于标测和表征心律失常及其治疗。
Ultrasound-based, Electromechanical Wave (EW) Imaging (EWI) can directly and entirely noninvasively map the transmural electromechanical activation in all four cardiac chambers in vivo. In this study, we assessed EWI repeatability and reproducibility, as well as its capability in localizing electronic and, for the first time, biological pacemakers in closed-chest, conscious canines. Electromechanical activation was obtained in six conscious animals during normal sinus rhythm (NSR), and idioventricular rhythms occurring in dogs in heart block instrumented with electronic and biological pacemakers (EPM and BPM respectively). After AV node ablation, dogs were implanted with an EPM in the right ventricular (RV) endocardial apex (n=4) and two additionally received a BPM at the left ventricular (LV) epicardial base (n=2). EWI was performed transthoracically during NSR, BPM, and EPM pacing, in conscious dogs, using an unfocused transmit sequence at 2000 frames/second. During NSR, the EW originated at the right atrium (RA), propagated to the left atrium (LA) and emerged from multiple sources in both ventricles. During EPM, the EW originated at the RV apex and propagated throughout both ventricles. During BPM, the EW originated from the LV basal lateral wall and subsequently propagated throughout the ventricles. EWI differentiated BPM from EPM and NSR and identified the distinct pacing origins. Isochrone comparison demonstrated that EWI was repeatable and reliable. These findings thus indicate the EWI potential to serve as a simple, noninvasive and direct imaging technology for mapping and characterizing arrhythmias as well as the treatments thereof.
登录
查看更多内容
影响因子：
3.8
作者：
Faris, OP;Evans, FJ;McVeigh, ER
通讯作者：
McVeigh, ER
DOI：
10.1109/tuffc.2007.528
发表时间：
2007-11-01
影响因子：
3.6
作者：
Lee, Wei-Ning;Ingrassia, Christopher M.;Konofagou, Elisa E.
通讯作者：
Konofagou, Elisa E.
影响因子：
37.8
作者：
DURRER, D;VANDAM, RT;ARZBAECHER, RC
通讯作者：
ARZBAECHER, RC
影响因子：
82.9
作者：
Ramanathan, C;Ghanem, RN;Rudy, Y
通讯作者：
Rudy, Y
DOI：
10.1111/j.1540-8167.2006.00736.x
发表时间：
2007-03-01
影响因子：
2.7
作者：
Barbuti, Andrea;Baruscotti, Mirko;DiFrancesco, Dario
通讯作者：
DiFrancesco, Dario