Neuroanatomical assessment of biological maturity.
Neuroanatomical assessment of biological maturity.
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DOI：
10.1016/j.cub.2012.07.002
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发表时间：
2012-09-25
期刊：
影响因子：
9.2
通讯作者：
Dale, Anders M.
中科院分区：
文献类型：
--
作者：
Brown, Timothy T.;Kuperman, Joshua M.;Chung, Yoonho;Erhart, Matthew;McCabe, Connor;Hagler, Donald J., Jr.;Venkatraman, Vijay K.;Akshoomoff, Natacha;Amaral, David G.;Bloss, Cinnamon S.;Casey, B. J.;Chang, Linda;Ernst, Thomas M.;Frazier, Jean A.;Gruen, Jeffrey R.;Kaufmann, Walter E.;Kenet, Tal;Kennedy, David N.;Murray, Sarah S.;Sowell, Elizabeth R.;Jernigan, Terry L.;Dale, Anders M.
结构MRI允许对发育中的人类大脑的解剖结构进行无与伦比的体内研究。二十多年来，MRI研究揭示了这个多方面成熟过程的许多新方面，大大增加了从死后研究中收集的科学知识。出生后的大脑发育明显延长，涉及大脑皮层[2-4]、皮层下[5]和小脑[6，7]结构的显著变化，以及白色物质纤维束[8-11]的显著结构变化（见[12]）。虽然许多工作已经描述了神经解剖学发展的孤立特征，但表征大脑解剖学的多维性质，捕获个体之间的不同发展阶段仍然是一个关键的挑战。利用多部位，多模态MRI的关键进展，并使用交叉验证的非线性建模，我们证明，发育大脑阶段可以比使用其他生物学措施更精确地评估，占年龄方差的92%以上。此外，我们的形态学、扩散率和信号强度的综合指标显示，同龄儿童之间的平均相位差异仅为1岁左右，首次揭示了人类大脑中成熟时间受到严格控制的潜在表型。视频摘要
Structural MRI allows unparalleled in vivo study of the anatomy of the developing human brain. For more than two decades [1], MRI research has revealed many new aspects of this multifaceted maturation process, significantly augmenting scientific knowledge gathered from postmortem studies. Postnatal brain development is notably protracted and involves considerable changes in cerebral cortical [2–4], subcortical [5], and cerebellar [6, 7] structures, as well as significant architectural changes in white matter fiber tracts [8–11] (see [12]). Although much work has described isolated features of neuroanatomical development, it remains a critical challenge to characterize the multidimensional nature of brain anatomy, capturing different phases of development among individuals. Capitalizing on key advances in multisite, multimodal MRI, and using cross-validated nonlinear modeling, we demonstrate that developmental brain phase can be assessed with much greater precision than has been possible using other biological measures, accounting for more than 92% of the variance in age. Further, our composite metric of morphology, diffusivity, and signal intensity shows that the average difference in phase among children of the same age is only about 1 year, revealing for the first time a latent phenotype in the human brain for which maturation timing is tightly controlled.Video Abstract
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影响因子：
25
作者：
Sowell, ER;Peterson, BS;Toga, AW
通讯作者：
Toga, AW
影响因子：
3.7
作者：
Bocklandt S;Lin W;Sehl ME;Sánchez FJ;Sinsheimer JS;Horvath S;Vilain E
通讯作者：
Vilain E
DOI：
10.1523/jneurosci.2180-11.2011
发表时间：
2011-08-10
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Glasser MF;Van Essen DC
通讯作者：
Van Essen DC
影响因子：
16.2
作者：
Giedd, Jay N.;Rapoport, Judith L.
通讯作者：
Rapoport, Judith L.
影响因子：
5.3
作者：
Ostby, Ylva;Tamnes, Christian K.;Walhovd, Kristine B.
通讯作者：
Walhovd, Kristine B.