Powassan Virus Disease in the United States, 2006-2016.
Powassan Virus Disease in the United States, 2006-2016.
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DOI：
10.1089/vbz.2017.2239
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发表时间：
2018-06
期刊：
影响因子：
--
通讯作者：
Hills SL
中科院分区：
文献类型：
--
作者：
Krow-Lucal ER;Lindsey NP;Fischer M;Hills SL
波瓦桑病毒 (POWV) 是一种蜱传黄病毒，可导致人类罕见但通常严重的疾病。 POWV 神经侵袭性疾病于 2001 年被添加到美国国家法定传染病清单中，非神经侵袭性疾病于 2004 年被添加到美国。此前，根据向疾病控制和预防中心 (CDC) 报告的病例对美国 POWV 疾病的流行病学进行了唯一一次审查，涵盖的时间段为 1999 年至 2005 年。我们描述了向美国疾病控制和预防中心 (CDC) 报告的实验室确诊 POWV 疾病病例的流行病学和临床特征。 2006 年至 2016 年 CDC 报告。这 11 年期间共报告了 99 例 POWV 疾病病例，其中包括 89 例神经侵袭性疾病病例和 10 例非神经侵袭性疾病病例。每年平均有 7 例病例（范围：1-22），其中报告病例数最多的是 2011 年（n=16）、2013 年（n=15）和 2016 年（n=22）。全年都有病例发生，但五月和六月达到高峰。报告的病例主要来自东北部和中北部各州。总体而言，72 例 (73%) 病例为男性，中位年龄为 62 岁（范围：3 个月至 87 岁）。在 11 例死亡病例中（11%），年龄均> 50 岁。神经侵袭性 POWV 疾病的平均年发病率为每 10 万人 0.0025 例。 POWV 病可能是一种严重的疾病，近年来诊断频率不断增加。然而，这可能反映出疾病意识的提高、检测可用性的提高以及监测工作的加强。对于居住在或曾前往适当地理区域的急性脑炎或无菌性脑膜炎患者，临床医生应考虑 POWV 病。
Powassan virus (POWV) is a tick-borne flavivirus that causes rare, but often severe, disease in humans. POWV neuroinvasive disease was added to the U.S. nationally notifiable disease list in 2001 and non-neuroinvasive disease was added in 2004. The only previous review of the epidemiology of POWV disease in the United States based on cases reported to the Centers for Disease Control and Prevention (CDC) covered the period from 1999 through 2005. We describe the epidemiology and clinical features of laboratory-confirmed POWV disease cases reported to CDC from 2006 through 2016. There were 99 cases of POWV disease reported during the 11-year period, including 89 neuroinvasive and 10 non-neuroinvasive disease cases. There was a median of 7 cases per year (range: 1–22), with the highest numbers of cases reported in 2011 (n=16), 2013 (n=15) and 2016 (n=22). Cases occurred throughout the year but peaked in May and June. Cases were reported primarily from northeastern and north-central states. Overall, 72 (73%) cases were in males and the median age was 62 years (range: 3 months – 87 years). Of the 11 (11%) cases who died, all were aged >50 years. The average annual incidence of neuroinvasive POWV disease was 0.0025 cases per 100,000 persons. POWV disease can be a severe disease and has been diagnosed with increased frequency in recent years. However, this might reflect increased disease awareness, improved test availability, and enhanced surveillance efforts. Clinicians should consider POWV disease in patients presenting with acute encephalitis or aseptic meningitis who are resident in, or have traveled to, an appropriate geographic region.
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影响因子：
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发表时间：
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Vector borne and zoonotic diseases (Larchmont, N.Y.)
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