Maternal serum dioxin levels and birth outcomes in women of Seveso, Italy.
Maternal serum dioxin levels and birth outcomes in women of Seveso, Italy.
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DOI：
10.1289/ehp.6080
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发表时间：
2003-06
影响因子：
10.4
通讯作者：
Patterson DG Jr
中科院分区：
文献类型：
--
作者：
Eskenazi B;Mocarelli P;Warner M;Chee WY;Gerthoux PM;Samuels S;Needham LL;Patterson DG Jr
2,3,7,8-四氯二苯并-（斜体）对（/斜体）-二恶英 (TCDD) 是一种普遍存在的环境污染物，在动物研究中与胎儿流产增加和出生体重降低有关。 1976 年，意大利塞维索附近的一家三氯苯酚工厂发生爆炸，导致人类居住人群中已知的最高 TCDD 暴露水平。 1996 年，我们启动了塞维索妇女健康研究，这是一项对居住在污染最严重地区（A 区和 B 区）的妇女进行回顾性队列研究。我们检查了 510 名妇女（总共 888 名怀孕）的妊娠结局与爆炸后不久收集的孕妇血清中测得的 TCDD 水平之间的关系。 97 例妊娠 (10.9%) 以自然流产 (SAB) 结束。 log(下标)10(/下标) TCDD 与 SAB 没有关联[调整后的比值比 (OR) = 0.8； 95% 置信区间 (CI), 0.6-1.2] 与出生体重（调整后 beta = -4 g；95% CI，-68 至 60）或小于胎龄 (SGA) 的出生（调整后 OR = 1.2；95% CI，0.8-1.8）。然而，暴露后前 8 年内怀孕与出生体重（调整后的 beta = -92 g；95% CI，-204 至 19）和 SGA（调整后 OR = 1.4；95% CI，0.6-2.9）的相关性更强。 TCDD 与调整后胎龄 1.0-1.3 天非显着性下降以及早产几率非显着性增加 20-50% 相关。 TCDD 对出生结果的影响仍有待观察，因为塞维索暴露最严重的妇女是最年轻的，也是最不可能怀孕的。
2,3,7,8-Tetrachlorodibenzo-(italic)para(/italic)-dioxin (TCDD), a ubiquitous environmental contaminant, is associated with increased fetal loss and reduced birth weight in animal studies. In 1976, an explosion at a trichlorophenol plant near Seveso, Italy, resulted in the highest TCDD exposure known in human residential populations. In 1996, we initiated the Seveso Women's Health Study, a retrospective cohort study of women who resided in the most contaminated areas, zones A and B. We examined the relation of pregnancy outcome in 510 women (888 total pregnancies) to maternal TCDD levels measured in serum collected shortly after the explosion. Ninety-seven pregnancies (10.9%) ended as spontaneous abortions (SABs). There was no association of log(subscript)10(/subscript) TCDD with SAB [adjusted odds ratio (OR) = 0.8; 95% confidence interval (CI), 0.6-1.2], with birth weight (adjusted beta = -4 g; 95% CI, -68 to 60), or with births that were small for gestational age (SGA) (adjusted OR = 1.2; 95% CI, 0.8-1.8). However, associations with birth weight (adjusted beta = -92 g; 95% CI, -204 to 19) and with SGA (adjusted OR = 1.4; 95% CI, 0.6-2.9) were stronger for pregnancies within the first 8 years after exposure. TCDD was associated with a 1.0-1.3 day nonsignificant adjusted decrease in gestational age and a 20-50% nonsignificant increase in the odds of preterm delivery. It remains possible that the effects of TCDD on birth outcomes are yet to be observed, because the most heavily exposed women in Seveso were the youngest and the least likely to have yet had a pregnancy.
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DOI：
10.1002/tcm.1770050404
发表时间：
1985-01-01
期刊：
TERATOGENESIS CARCINOGENESIS AND MUTAGENESIS
影响因子：
--
作者：
CONSTABLE, JD;HATCH, MC
通讯作者：
HATCH, MC
影响因子：
2.7
作者：
COURTNEY, KD
通讯作者：
COURTNEY, KD
二恶英毒性的机制：与风险评估的关系。
影响因子：
10.4
作者：
Birnbaum, L S
通讯作者：
Birnbaum, L S
DOI：
10.1080/026520300283351
发表时间：
2000-04-01
影响因子：
2.9
作者：
Birnbaum, LS;Tuomisto, J
通讯作者：
Tuomisto, J
影响因子：
7.7
作者：
BURNS, TL;MOLL, PP;LAUER, RM
通讯作者：
LAUER, RM