The development of sensorimotor cortical oscillations is mediated by pubertal testosterone.
The development of sensorimotor cortical oscillations is mediated by pubertal testosterone.
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DOI：
10.1016/j.neuroimage.2022.119745
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发表时间：
2022-12-01
期刊：
影响因子：
5.7
通讯作者：
Wilson, Tony W.
中科院分区：
文献类型：
--
作者：
Fung, Madison H.;Heinrichs-Graham, Elizabeth;Taylor, Brittany K.;Frenzel, Michaela R.;Eastman, Jacob A.;Wang, Yu-Ping;Calhoun, Vince D.;Stephen, Julia M.;Wilson, Tony W.
青春期是激素大幅波动的时期，青春期激素能够调节发育中大脑的结构和功能变化。许多先前的研究已经描述了与运动相关的神经振荡反应的特征，包括运动开始前的β事件相关去同步化（ERD）、与运动执行同时发生的γ和θ反应，以及运动结束后的运动后β反弹（PMBR）反应。虽然有一些研究调查了这些服务于运动控制的神经振荡的发展轨迹，但青春期激素水平对这些动态变化成熟过程的影响尚未得到研究。由于个体之间青春期的时间和节奏差异很大，青春期激素可能对运动皮层振荡的成熟产生独特的影响，这与年龄等其他发展指标不同。在当前的研究中，我们使用脑磁图（MEG）对这些振荡进行了量化，并将实际年龄和内源性睾酮的测量值作为69名青少年从童年到青春期过渡期间的发展指标。中介分析揭示了β ERD复杂的成熟模式，其中睾酮通过直接和间接作用预测自发基线和ERD功率。年龄（而非青春期激素）预测了与运动相关的θ，并且对于γ或PMBR反应，未发现振荡反应与发展指标之间存在关系。这些发现为青春期激素如何影响与运动相关的振荡提供了新的见解，并强调了在整个青春期运动皮层动态的持续发展。
Puberty is a period of substantial hormonal fluctuations, and pubertal hormones can modulate structural and functional changes in the developing brain. Many previous studies have characterized the neural oscillatory responses serving movement, which include a beta event-related desynchronization (ERD) preceding movement onset, gamma and theta responses coinciding with movement execution, and a post-movement beta-rebound (PMBR) response following movement offset. While a few studies have investigated the developmental trajectories of these neural oscillations serving motor control, the impact of pubertal hormone levels on the maturation of these dynamics has not yet been examined. Since the timing and tempo of puberty varies greatly between individuals, pubertal hormones may uniquely impact the maturation of motor cortical oscillations distinct from other developmental metrics, such as age. In the current study we quantified these oscillations using magnetoencephalography (MEG) and utilized chronological age and measures of endogenous testosterone as indices of development during the transition from childhood to adolescence in 69 youths. Mediation analyses revealed complex maturation patterns for the beta ERD, in which testosterone predicted both spontaneous baseline and ERD power through direct and indirect effects. Age, but not pubertal hormones, predicted motor-related theta, and no relationships between oscillatory responses and developmental metrics were found for gamma or PMBR responses. These findings provide novel insight into how pubertal hormones affect motor-related oscillations, and highlight the continued development of motor cortical dynamics throughout the pubertal period.
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DOI：
10.1073/pnas.0402680101
发表时间：
2004-05-25
影响因子：
11.1
作者：
Gogtay, N;Giedd, JN;Thompson, PM
通讯作者：
Thompson, PM
运动后β振荡在运动终止中的功能作用。
影响因子：
3.1
作者：
Heinrichs-Graham E;Kurz MJ;Gehringer JE;Wilson TW
通讯作者：
Wilson TW
影响因子：
3.7
作者：
Bramen JE;Hranilovich JA;Dahl RE;Chen J;Rosso C;Forbes EE;Dinov ID;Worthman CM;Sowell ER
通讯作者：
Sowell ER
影响因子：
3.7
作者：
Fung, Madison H.;Taylor, Brittany K.;Wilson, Tony W.
通讯作者：
Wilson, Tony W.
影响因子：
1.8
作者：
Austin, PC;Tu, JV
通讯作者：
Tu, JV