Aging-induced microbleeds of the mouse thalamus compared to sensorimotor and memory defects.
Aging-induced microbleeds of the mouse thalamus compared to sensorimotor and memory defects.
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DOI：
10.1016/j.neurobiolaging.2020.11.017
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发表时间：
2021-04
影响因子：
4.2
通讯作者：
Morgan KG
中科院分区：
文献类型：
--
作者：
Wang Y;Taylor E;Zikopoulos B;Seta F;Huang N;Hamilton JA;Kantak KM;Morgan KG
本研究的目的是探讨衰老与脑血管健康之间的关系。研究了三个年龄组的小鼠，3个月，17-18个月和24个月，与年轻人，中年人和老年人个体相当。普鲁士蓝组织学和FISP T2* 加权MRI被用来量化不同年龄组的大脑结构变化。新物体识别（NOR）测试用于评估与解剖变化相关的行为变化。本研究首次表明，丘脑是衰老诱导的血管损伤小鼠模型中最脆弱的脑区。这里提供的MRI数据记录了丘脑损伤累积的时间轴。组织学数据显示，大多数血管损伤积聚在腹后核（VP）和丘脑背内侧核（MD）。功能研究表明，衰老引起的丘脑血管损伤与记忆和感觉运动缺陷有关。目前的研究指出，与年龄相关的血管疾病可能是早在中年时不可逆脑损伤的一个因素。
The aim of the present study was to investigate the relationship between aging and brain vasculature health. Three age groups of mice, 3 months, 17–18 months and 24 months, comparable to young adult, middle age and old human individuals were studied. Prussian blue histology, and FISP T2*-weighted MRI were used to quantify structural changes in the brain across age groups. The Novel Object Recognition (NOR) test was used to assess behavioral changes associated with anatomical changes. The present study is the first to show that the thalamus is the most vulnerable brain region in the mouse model for aging-induced vascular damage. MRI data presented here document the timeline of accumulation of thalamic damage. Histological data reveal that the majority of vascular damage accumulates in the ventroposterior nucleus (VP) and mediodorsal thalamic nucleus(MD). Functional studies indicate that aging-induced vascular damage in the thalamus is associated with memory and sensorimotor deficits. The present study points to the possibility that aging-associated vascular disease may be a factor in irreversible brain damage as early as middle age.
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