Methamidophos, an Organophosphorus Insecticide, Induces Pro-aggressive Behaviour in Mice.
Methamidophos, an Organophosphorus Insecticide, Induces Pro-aggressive Behaviour in Mice.
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DOI：
10.1007/s12640-017-9750-9
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发表时间：
2017-10
影响因子：
3.7
通讯作者：
Sampaio KN
中科院分区：
文献类型：
--
作者：
do Nascimento CP;Maretto GX;Marques GLM;Passamani LM;Abdala AP;Schenberg LC;Beijamini V;Sampaio KN
虽然有证据表明，接触有机磷（OP）农药诱导神经行为障碍，很少有人知道OP的攻击行为的影响。我们的研究调查了反复暴露于OP农药甲胺磷对隔离诱导的小鼠攻击行为的影响。将47只雄性小鼠单独圈养一个月。然后将社会隔离的动物与标准的非隔离对手对抗15分钟（预处理试验），并记录攻击性和一般探索性行为的潜伏期和频率。根据给药前试验中攻击行为的存在，将小鼠分为隔离诱导的攻击性和非攻击性。然后用甲胺磷（3.5毫克/千克/天，n=22，ip）或盐水（1毫升/千克/天，对照组，n=25，ip）处理所有小鼠7天，并进行第二次试验。反复接触甲胺磷诱导非攻击性小鼠的攻击行为。用甲胺磷处理还降低了血浆丁酰胆碱酯酶和脑乙酰胆碱酯酶的活性。这些结果表明，甲胺磷对社交孤立的小鼠具有促进攻击性的作用。
Although evidence indicates that exposure to organophosphorus (OP) pesticides induces neurobehavioral disorders, little is known about the effects of OP on aggressive behaviour. Our study investigated the effects of repeated exposure to an OP pesticide, methamidophos, on the isolation-induced aggressive behaviour in mice. Forty seven male mice were individually housed for a month. Socially isolated animals were then confronted with a standard non-isolated opponent for 15 minutes (pre-treatment trial), and the latency and frequency of aggressive and general exploratory behaviours were recorded. Based on the presence of attack behaviour in the pre-treatment trial, mice were classified as isolation-induced aggressive and non-aggressive. All mice were then treated for seven days with methamidophos (3.5 mg/kg/day, n=22, ip) or saline (1 mL/kg/day, control group, n=25, ip) and a second trial performed. Repeated exposure to methamidophos induced attack behaviour in non-aggressive mice. The treatment with methamidophos also decreased plasma butyrylcholinesterase and brain acetylcholinesterase activity. These results suggest that methamidophos has a pro-aggressive effect on socially isolated mice.
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影响因子：
5.8
作者：
ELLMAN, GL;COURTNEY, KD;FEATHERSTONE, RM
通讯作者：
FEATHERSTONE, RM
DOI：
10.1097/01.jom.0000235938.70212.dd
发表时间：
2006-10-01
影响因子：
3.2
作者：
Beseler, Cheryl;Stallones, Lorann;Kamel, Freya
通讯作者：
Kamel, Freya
影响因子：
8.3
作者：
Amr, MM;Halim, ZS;Moussa, SS
通讯作者：
Moussa, SS
影响因子：
3.6
作者：
DAMATO, FR;CASTELLANO, C
通讯作者：
CASTELLANO, C
DOI：
10.1176/appi.neuropsych.12030060
发表时间：
2013
期刊：
The Journal of neuropsychiatry and clinical neurosciences
影响因子：
--
作者：
Alcorn JL 3rd;Gowin JL;Green CE;Swann AC;Moeller FG;Lane SD
通讯作者：
Lane SD