Self-reported neglect, amygdala volume, and symptoms of anxiety in adolescent boys.
Self-reported neglect, amygdala volume, and symptoms of anxiety in adolescent boys.
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DOI：
10.1016/j.chiabu.2018.03.016
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发表时间：
2018-06
影响因子：
4.8
通讯作者：
Gotlib IH
中科院分区：
文献类型：
--
作者：
Roth MC;Humphreys KL;King LS;Gotlib IH
心理社会忽视的经历会影响发育中的大脑，并可能使个体面临更大的焦虑风险。这一领域的大多数研究都集中在经历过严重心理社会剥夺的儿童身上;目前尚不清楚社区样本中经历的忽视的典型变化是否会产生与极端样本中记录的相同的神经生物学后果。本研究探讨了自报的儿童忽视，杏仁核体积，焦虑症状之间的协会在社区样本的138名青少年年龄在9至15岁（43%男性）。线性混合模型产生了忽视，性别和大脑半球的三向相互作用，反映了忽视和右杏仁核体积的男孩之间的显着正相关。进一步的分析表明，右杏仁核体积显着介导男孩的忽视和焦虑症状之间的关联。这些发现与先前的报告一致，即先前被机构化的儿童的杏仁核体积更大，并且与记录的剥夺和焦虑症状之间的关联一致。结果表明，儿童忽视边缘系统结构的影响是性别特异性和偏侧化，并提供支持的神经机制，儿童忽视以后的困难，情绪功能。
Experiences of psychosocial neglect affect the developing brain and may place individuals at increased risk for anxiety. The majority of research in this area has focused on children who have experienced severe psychosocial deprivation; it is not clear whether typical variation in neglect experienced in community samples would have the same neurobiological consequences as those documented in extreme samples. The present study examined the associations among self-reported childhood neglect, amygdala volume, and anxiety symptoms in a community sample of 138 adolescents ages 9 to 15 years (43% male). Linear mixed modeling yielded a three-way interaction of neglect, sex, and brain hemisphere, reflecting a significant positive association between neglect and right amygdala volume in boys. Additional analyses indicated that right amygdala volume significantly mediated the association between neglect and anxiety symptoms in boys. These findings are consistent with previous reports of larger amygdala volumes in previously institutionalized children, and with documented associations between caregiving deprivation and anxiety symptoms. The results suggest that the effects of childhood neglect on limbic structures are sex-specific and lateralized, and provide support for a neural mechanism relating childhood neglect to later difficulties in emotional functioning.
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