Amygdala volume and hypothalamic-pituitary-adrenal axis reactivity to social stress.
Amygdala volume and hypothalamic-pituitary-adrenal axis reactivity to social stress.
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DOI：
10.1016/j.psyneuen.2017.07.487
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发表时间：
2017-11
影响因子：
3.7
通讯作者：
Halligan SL
中科院分区：
文献类型：
--
作者：
Barry TJ;Murray L;Fearon P;Moutsiana C;Johnstone T;Halligan SL
杏仁核体积与应激相关的皮质醇反应性无关。然而，产后抑郁母亲的后代表现出了一种关联。对这些后代来说，体积越小，反应性越强。这种关联与年龄匹配的对照后代有关。杏仁核在情绪处理中起着核心作用，并对下丘脑-垂体-肾上腺（HPA）轴具有激活作用。杏仁核的结构变化与早期的逆境有关，原则上，通过影响大脑对压力刺激的反应方式，可能会导致后来出现的情绪病理。本研究考察了在发育早期有或没有经历过母亲产后抑郁症（PND）的年轻人（分别称为PND后代和对照组）中，杏仁核体积和皮质醇分泌对社会压力的反应之间的关系。层次线性模型（HLM）显示，在样本范围内，没有证据表明杏仁核总体积，或单独取的左右半球杏仁核体积与皮质醇反应性之间存在关系。出乎意料的是，对于PND后代，更大的右半球杏仁核体积与应激反应中较低的皮质醇反应性相关，这种影响在对照组后代中并不明显。我们的结论是，杏仁核体积和应激反应之间的关系可能不像以前的模型所表明的那样清楚。
Amygdala volumes were not associated with stress-related cortisol reactivity. However, postnatally depressed mothers’ offspring showed an association. For these offspring, smaller volumes corresponded with heightened reactivity. This association was relative to age-matched control offspring. The amygdala plays a central role in emotional processing and has an activating influence on the hypothalamic-pituitary-adrenal (HPA) axis. Structural changes in the amygdala have been associated with early adversity and, in principle, may contribute to the later emergence of emotional pathologies by influencing the way that the brain responds to stress provocation. The present study examined the relationship between amygdala volumes and cortisol secretion in response to a social stressor among young adults who were or were not exposed to maternal postnatal depression (PND) early in development (referred to as PND offspring and controls, respectively). Hierarchical Linear Modelling (HLM) revealed that, on a sample-wide level, there was no evidence of a relationship between total amygdala volume, or the volume of the right or left hemisphere amygdala taken separately, and cortisol reactivity. Unexpectedly, for PND offspring, larger right hemisphere amygdala volume was associated with lower cortisol reactivity in response to stress, an effect that was not apparent in control offspring. We conclude that the relationship between amygdala volumes and stress reactivity may not be as clear as previous models suggested.
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影响因子：
2.3
作者：
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通讯作者：
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