Increased human leukocyte antigen-G expression at the maternal-fetal interface is associated with preterm birth.
Increased human leukocyte antigen-G expression at the maternal-fetal interface is associated with preterm birth.
复制标题
DOI：
10.3109/14767058.2014.921152
复制
发表时间：
2015-03
期刊：
影响因子：
--
通讯作者：
Mysorekar IU
中科院分区：
文献类型：
--
作者：
Stout MJ;Cao B;Landeau M;French J;Macones GA;Mysorekar IU
母胎界面必须调节免疫功能，以允许胎儿细胞耐受，同时仍对病原体做出反应以抑制感染。人类白细胞抗原-G (HLA-G) 是 Ib 类主要组织相容性复合蛋白，参与母胎耐受。我们推测胎盘 HLA-G 表达的改变会使女性容易早产。本研究的目的是比较足月和早产人类胎盘母胎界面中 HLA-G 的表达。我们对参加组织样本和临床数据联盟的女性的人胎盘基底板样本进行了横断面研究。使用免疫组织化学和数字显微分析来定量早产和足月胎盘基底板中 HLA-G 蛋白的表达。 149 例单胎妊娠中，29.5% 发生 <37 周的早产。 HLA-G阳性细胞占据基底板的三分之一，早产胎盘的HLA-G阳性面积比足月胎盘增加14%（足月胎盘为32.1%，早产胎盘为36.6%）。虽然半同种异体胎儿的母体耐受性需要 HLA-G，但母体胎儿界面较高水平的 HLA-G 表达与早产相关。
The maternal-fetal interface must modulate immune function to allow tolerance of fetal cells while still reacting to pathogens to suppress infection. Human leukocyte antigen-G (HLA-G) is a class Ib major histocompatibility complex protein involved in maternal-fetal tolerance. We posited that alterations in placental HLA-G expression predispose women to preterm birth. The aim of this study was to compare HLA-G expression in the maternal-fetal interface of term versus preterm human placentas. We performed a cross-sectional study of specimens from the basal plate of the human placenta from women enrolled in a tissue specimen and clinical data consortium. Immunohistochemistry with digital microscopic analysis was used to quantify HLA-G protein expression in the basal plate from preterm and term placentas. Preterm birth <37 weeks occurred in 29.5% of 149 singleton pregnancies. HLA-G-positive cells occupied one-third of the basal plates, and the HLA-G-positive area was increased by 14% in placentas from preterm births than in those from term births (32.1% in term placentas versus 36.6% in preterm placentas). Although HLA-G is required for maternal tolerance of the semi-allogeneic fetus, higher levels of HLA-G expression at the maternal fetal interface is associated with preterm birth.
登录
查看更多内容
影响因子：
2.7
作者：
Paul, P;Rouas-Freiss, N;Carosella, ED
通讯作者：
Carosella, ED
影响因子：
2.7
作者：
Mysorekar, Indira U.;Cao, Bin
通讯作者：
Cao, Bin
影响因子：
4.4
作者：
Fournel, S;Aguerre-Girr, M;Le Bouteiller, P
通讯作者：
Le Bouteiller, P
DOI：
10.3109/14767050903019684
发表时间：
2009-12
期刊：
The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians
影响因子：
--
作者：
Kusanovic JP;Romero R;Jodicke C;Mazaki-Tovi S;Vaisbuch E;Erez O;Mittal P;Gotsch F;Chaiworapongsa T;Edwin SS;Pacora P;Hassan SS
通讯作者：
Hassan SS
影响因子：
4
作者：
Kanai, T;Fujii, T;Taketani, Y
通讯作者：
Taketani, Y