Striatal dopamine type 2 receptor availability in anorexia nervosa.
Striatal dopamine type 2 receptor availability in anorexia nervosa.
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DOI：
10.1016/j.pscychresns.2015.06.013
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发表时间：
2015-09-30
影响因子：
11.3
通讯作者：
Timothy Walsh B
中科院分区：
文献类型：
--
作者：
Broft A;Slifstein M;Osborne J;Kothari P;Morim S;Shingleton R;Kenney L;Vallabhajosula S;Attia E;Martinez D;Timothy Walsh B
神经性厌食症的神经生物学尚不完全清楚。在这里，我们利用放射性示踪剂[11C]拉氯必利的PET成像来测量神经性厌食症患者纹状体多巴胺2型(D2)受体的可用性。参加住院治疗的25名患有神经性厌食症的女性和25名对照受试者参加了试验。患者接受了两次PET示踪剂[11C]拉氯必利扫描：一次是在体重不足时，一次是在体重恢复时。对照组受试者接受一次正电子发射计算机断层扫描。在初步分析中，体重不足患者(n=21)和对照组(n=25)的纹状体D2受体结合电位没有显著差异。亚区分析(感觉运动纹状体、联合纹状体、边缘纹状体)未显示组间差异。在完成两次扫描的患者中(n=15)，体重恢复后纹状体D2受体结合潜力没有检测到变化。在这个样本中，神经性厌食症患者和对照组之间纹状体D2受体结合电位没有差异。体重恢复与纹状体D2受体结合的改变无关。这些发现表明，这种疾病的奖赏加工障碍并不是由于D2受体特征的异常所致，其他与奖赏相关的神经靶点可能具有更大的相关性。
The neurobiology of anorexia nervosa remains incompletely understood. Here we utilized PET imaging with the radiotracer [11C]raclopride to measure striatal dopamine type 2 (D2) receptor availability in patients with anorexia nervosa. 25 women with anorexia nervosa who were receiving treatment in an inpatient program participated, as well as 25 control subjects. Patients were scanned up to two times with the PET tracer [11C]raclopride: once while underweight, and once upon weight restoration. Control subjects underwent one PET scan. In the primary analyses, there were no significant differences between underweight patients (n=21) and control subjects (n=25) in striatal D2 receptor binding potential. Analysis of subregions (sensorimotor striatum, associative striatum, limbic striatum) did not reveal differences between groups. In patients completing both scans (n=15), there were no detectable changes in striatal D2 receptor binding potential after weight restoration. In this sample, there were no differences in striatal D2 receptor binding potential between patients with anorexia nervosa and control subjects. Weight restoration was not associated with a change in striatal D2 receptor binding. These findings suggest that disturbances in reward processing in this disorder are not attributable to abnormal D2 receptor characteristics, and that other reward-related neural targets may be of greater relevance.
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