Refining the Empirical Constraints on Computational Models of Spatial Working Memory in Schizophrenia.
Refining the Empirical Constraints on Computational Models of Spatial Working Memory in Schizophrenia.
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DOI：
10.1016/j.bpsc.2020.05.003
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发表时间：
2020-09
期刊：
影响因子：
--
通讯作者：
Luck SJ
中科院分区：
文献类型：
--
作者：
Gold JM;Bansal S;Anticevic A;Cho YT;Repovš G;Murray JD;Hahn B;Robinson BM;Luck SJ
精神分裂症患者的空间工作记忆(Swm)障碍已经得到了很好的证明。在这里，我们提供了一个精神分裂症患者工作记忆表现的微电路模型的全面测试，该模型基于兴奋和抑制过程的假设失衡，预测了延长延迟时间和干扰物的增强效果。模型预测在41名临床稳定的精神分裂症患者(PSZ)和32名健康对照受试者(HCS)中进行了测试，这些受试者正在执行空间WM任务。在一种情况下，单个目标位置之后会有0、2、4或8秒的延迟。在第二种情况下，在距离原始目标位置20度、30度、40度、50度或90度的4秒延迟间隔内出现干扰物。PSZ表现出比HCS更不精确的swm表征，并且PSZ的记忆漂移速率大于HCS。相对于HCS，PSZ的空间回忆反应更多地被靠近目标位置的干扰物所排斥，而更多地被远离目标位置的干扰物所吸引。对远距离干扰物的吸引程度与没有干扰物时记忆漂移的速度相关。与微电路模型一致，PSZ相对于HCS表现出更大的漂移速率和对远处干扰物的更大吸引力。这两种影响是相互关联的，与它们产生于单一潜在机制的说法一致。然而，模型没有预测到附近干扰物产生的排斥效应，因此需要更新建模框架。
Impairments in spatial working memory (sWM) have been well-documented in schizophrenia. Here we provide a comprehensive test of a microcircuit model of WM performance in schizophrenia, which predicts enhanced effects of increasing delay duration and distractors based on a hypothesized imbalance of excitatory and inhibitory processes. Model predictions were tested in 41 clinically stable people with schizophrenia (PSZ) and 32 healthy control subjects (HCS) performing a spatial WM task. In one condition, a single target location was followed by delays of 0, 2, 4, or 8 seconds. In a second condition, distractors were presented during the 4-second delay interval at 20, 30, 40, 50, or 90 degrees from the original target location. PSZ showed less precise sWM representations than HCS, and the rate of memory drift over time was greater in PSZ than in HCS. Relative to HCS, the spatial recall responses of PSZ were more repelled by distractors presented close to the target location and more attracted by distractors presented far from the target location. The degree of attraction to distant distractors was correlated with the rate of memory drift in the absence of distractors. Consistent with the microcircuit model, PSZ exhibited both a greater rate of drift and greater attraction to distant distractors relative to HCS. These two effects were correlated, consistent with the proposal that they arise from a single underlying mechanism. However, the repulsion effects produced by nearby distractors were not predicted by the model and thus require an updated modeling framework.
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影响因子：
16.2
作者：
Wang M;Yang Y;Wang CJ;Gamo NJ;Jin LE;Mazer JA;Morrison JH;Wang XJ;Arnsten AF
通讯作者：
Arnsten AF
影响因子：
--
作者：
Gold, James M.;Hahn, Britta;Zhang, Wei Wei;Robinson, Benjamin M.;Kappenman, Emily S.;Beck, Valerie M.;Luck, Steven J.
通讯作者：
Luck, Steven J.
影响因子：
64.8
作者：
BLAKEMOR.C;CARPENTE.RH;GEORGESO.MA
通讯作者：
GEORGESO.MA
影响因子：
--
作者：
Tek, C;Gold, J;Buchanan, RW
通讯作者：
Buchanan, RW
影响因子：
10.6
作者：
Andreasen, Nancy C.;Pressler, Marcus;Nopoulos, Peg;Miller, Del;Ho, Beng-Choon
通讯作者：
Ho, Beng-Choon