Amygdala and nucleus accumbens involvement in appetitive extinction
Amygdala and nucleus accumbens involvement in appetitive extinction
复制标题
杏仁核和伏隔核参与食欲消退
DOI：
10.1002/hbm.24915
复制
发表时间：
2020
影响因子：
4.8
通讯作者：
Klucken
中科院分区：
文献类型：
--
作者：
Tapia León I;Klucken
食欲条件反射的消退被认为是治疗成瘾等精神疾病的重要模型。然而，很少有研究调查其神经相关性。因此，我们在一个包括所有性别（N= 76，40名女性）的大型人类样本中研究了食欲消退的神经相关性，以复制和扩展先前研究的结果。在差异食欲条件反射中，一个刺激（CS+）与赢得金钱奖励的机会配对，而另一个刺激（CS-）则没有。在第二天的食欲消退期间，CS+和CS-都没有得到加强。成功收购的食欲调节后，灭绝阶段引起显着减少的效价和唤醒评级对CS+和显着减少皮肤电导反应的CS+从早期到晚期灭绝。在神经水平上，早期消退在dACC和海马中显示出显著的差异（CS+ − CS−）激活，而vACC和尾状核的参与没有复制。杏仁核和杏仁核的差异激活在晚期灭绝的复制，杏仁核表现出显着更高的差异激活在晚期灭绝的早期阶段相比。我们表现出可辨别的信号奖励学习和灭绝后，杏仁核和杏仁核的子区域灭绝学习。这种成功的复制强调了杏仁核和杏仁核在人类食欲消退神经模型中的作用，而这种作用以前只基于动物的发现。
Extinction of appetitive conditioning is regarded as an important model for the treatment of psychiatric disorders like addiction. However, very few studies have investigated its neural correlates. Therefore, we investigated neural correlates of appetitive extinction in a large human sample including all genders (N= 76, 40 females) to replicate and extend results from a previous study. During differential appetitive conditioning, one stimulus (CS+) was paired with the chance to win a monetary reward, whereas another stimulus (CS−) was not. During appetitive extinction on the next day, neither the CS+ nor the CS− were reinforced. After successful acquisition of appetitive conditioning, the extinction phase elicited significant reductions of valence and arousal ratings toward the CS+ and a significant reduction in skin conductance responses to the CS+ from early to late extinction. On a neural level, early extinction showed significant differential (CS+ − CS−) activation in dACC and hippocampus, whereas involvement of the vACC and caudate nucleus did not replicate. The differential activation of amygdala and nucleus accumbens during late extinction was replicated, with the amygdala displaying significantly higher differential activation during the late phase of extinction as compared to the early phase of extinction. We show discernible signals for reward learning and extinction in subregions of amygdala and nucleus accumbens after extinction learning. This successful replication underlines the role of nucleus accumbens and amygdala in neural models of appetitive extinction in humans that was previously only based on animal findings.
登录
查看更多内容
影响因子：
3.7
作者：
Pineles SL;Orr MR;Orr SP
通讯作者：
Orr SP
影响因子：
2.7
作者：
Janak, PH;Chen, MT;Caulder, T
通讯作者：
Caulder, T
影响因子：
16.2
作者：
Tobler, Philippe N.;Fletcher, Paul C.;Schultz, Wolfram
通讯作者：
Schultz, Wolfram
学会喜欢厌恶：反调节的神经元相关性
影响因子：
2.9
作者：
J. Schweckendiek;T. Klucken;C. Merz;S. Kagerer;B. Walter;D. Vaitl;R. Stark
通讯作者：
R. Stark
让我们来谈谈性别——人类恐惧条件反射的差异
影响因子：
5
作者：
C. Merz;Valerie L. Kinner;O. Wolf
通讯作者：
O. Wolf