Thalamic atrophy moderates associations among aerobic fitness, cognitive processing speed, and walking endurance in persons with multiple sclerosis.
Thalamic atrophy moderates associations among aerobic fitness, cognitive processing speed, and walking endurance in persons with multiple sclerosis.
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DOI：
10.1007/s00415-022-11205-9
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发表时间：
2022-10
影响因子：
6
通讯作者：
Zivadinov, Robert
中科院分区：
文献类型：
--
作者：
Sandroff, Brian M.;Motl, Robert W.;Roman, Cristina A. F.;Wylie, Glenn R.;DeLuca, John;Cutter, Gary R.;Benedict, Ralph H. B.;Dwyer, Michael G.;Zivadinov, Robert
丘脑萎缩（TA）代表多发性硬化症（MS）患者中神经变性和相关功能障碍/身体和认知功能下降的生物标志物。有氧健身作为运动训练的终点，代表了MS功能恢复的一个有希望的目标，但尚不清楚TA是否会影响这些效果。这项横断面研究探讨了有氧健身是否与MS患者的认知处理速度和步行耐力有差异。44名完全行走的MS患者完成了用于测量有氧适能（VO 2 peak）的分级运动试验，并接受了用于测量TA的3 T MRI、符号数字模态试验（SDMT）和6分钟步行（6 MW）。我们对总的VO 2峰值、SDMT和6 MW评分以及有和无TA的患者进行了斯皮尔曼相关性分析。我们应用Fisher z检验比较基于TA状态的相关性。当控制年龄、EDSS评分和萎缩的总体MRI测量时，VO 2峰值与SDMT评分密切相关（λ = 0.74，p < 0.01）和6 MW性能（P = 0.77，p < 0.01），而VO 2峰值与SDMT评分无关（Δ =-0.01，p = 0.99）或6 MW性能（Δ = 0.25，p = 0.38）。TA组VO 2 peak与SDMT（z = 2.86，p < 0.01）和VO 2 peak与6 MW（z = 2.33，p = 0.02）之间的相关性显著更强。这项研究提供了初步证据，表明TA患者的有氧健身、认知处理速度和步行耐力之间存在强有力的选择性关联，并将其作为MS相关神经退行性变的生物标志物。这些数据支持TA作为MS患者有氧健身，认知处理速度和步行耐力之间的关联的调节剂。未来的研究应仔细考虑TA的作用时，设计试验的有氧运动，认知和流动性MS。
Thalamic atrophy (TA) represents a biomarker of neurodegeneration and associated dysfunction/decline in physical and cognitive functioning among persons with multiple sclerosis (MS). Aerobic fitness, as an end point of exercise training, represents a promising target for restoring function in MS, but it is unknown if such effects differ by TA. This cross-sectional study examined whether aerobic fitness was differentially associated with cognitive processing speed and walking endurance in persons with MS who present with and without TA. 44 fully ambulatory persons with MS completed a graded exercise test for measuring aerobic fitness (VO2peak) and underwent 3T MRI for measuring TA, the Symbol Digit Modalities Test (SDMT), and the 6-min walk (6MW). We performed Spearman correlations (rs) among VO2peak, SDMT, and 6MW scores overall, and in persons with and without TA. We applied Fisher’s z-test for comparing correlations based on TA status. When controlling for age, EDSS score, and global MRI measures of atrophy, VO2peak was strongly associated with SDMT scores (prs = 0.74, p < 0.01) and 6MW performance (prs = 0.77, p < 0.01) in persons with TA, whereas VO2peak was not associated with SDMT scores (prs = − 0.01, p = 0.99) or 6MW performance (prs = 0.25, p = 0.38) in those without TA. The correlations between VO2peak and SDMT (z = 2.86, p < 0.01) and VO2peak and 6MW (z = 2.33, p = 0.02) were significantly stronger in the TA group. This study provides initial evidence of strong, selective associations among aerobic fitness, cognitive processing speed, and walking endurance in persons with TA as a biomarker for MS-related neurodegeneration. Such data support TA as a moderator of the association among aerobic fitness, cognitive processing speed, and walking endurance in persons with MS. Future research should carefully consider the role of TA when designing trials of aerobic exercise, cognition, and mobility in MS.
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影响因子：
11.2
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