Estimating age-specific cumulative incidence for the 2009 influenza pandemic: a meta-analysis of A(H1N1)pdm09 serological studies from 19 countries.
Estimating age-specific cumulative incidence for the 2009 influenza pandemic: a meta-analysis of A(H1N1)pdm09 serological studies from 19 countries.
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估计2009年流感大流行的年龄特异性累积发生率：来自19个国家的A（H1N1）PDM09血清学研究的荟萃分析。
DOI：
10.1111/irv.12074
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发表时间：
2013-09
影响因子：
4.4
通讯作者：
H1N1pdm serology working group
中科院分区：
文献类型：
--
作者：
Van Kerkhove MD;Hirve S;Koukounari A;Mounts AW;H1N1pdm serology working group
2009年甲型H1N1流感大流行（H1N1pdm）的全球影响尚未得到充分了解。我们使用已发表和未发表的H1N1pdm血清流行病学研究的数据，估计H1N1pdm病毒交叉反应抗体的总体和年龄特异性患病率以及大流行第一年的H1N1pdm感染率。每项研究的主要聚集H1N1pdm血清学数据按标准化年龄组分层，并根据血清收集时间与国家或次国家H1N1pdm峰值活性的关系进行评价。使用充分描述和标准化的血凝抑制（HI滴度≥ 32或≥ 40）和微量中和（MN ≥ 40）实验室试验评估血清阳性。H1N1pdm病毒交叉反应性抗体的流行率是使用大流行开始前收集的血清进行研究估计的。（2004年至2009年4月）; H1N1pdm累积发病率是在收集大流行前和大流行后血清的研究中估计的; H1N1pdm血清阳性率仅从大流行后血清（2009年12月至2010年6月期间收集）的研究中计算。来自19个国家/行政区（澳大利亚、加拿大、中国、芬兰、法国、德国、中国香港特别行政区、印度、伊朗、意大利、日本、荷兰、新西兰、挪威、留尼汪岛、新加坡、英国、美国和越南）的27项已发表/未发表研究的数据符合纳入条件。交叉反应性抗体的总体年龄标准化流行前患病率为5%（95%CI 3 - 7%），并因年龄而异，≥ 65岁人群的患病率最高（14%95%CI 8 - 24%）。总体年龄标准化H1N1pdm累积发病率为24%（95%CI 20 - 27%），并因年龄而异，5 - 19岁儿童（47%95%CI 39 - 55%）和0 - 4岁儿童（36%95%CI 30 - 43%）的发病率最高。我们的研究结果为H1N1大流行的全球影响提供了独特的见解，并强调了血清流行病学研究标准化的必要性，并将其纳入大流行前的准备计划。我们的研究结果与最近的全球大流行呼吸道相关死亡率估计值相结合，表明大流行病毒的病死率约为0.02%。
The global impact of the 2009 influenza A(H1N1) pandemic (H1N1pdm) is not well understood. We estimate overall and age‐specific prevalence of cross‐reactive antibodies to H1N1pdm virus and rates of H1N1pdm infection during the first year of the pandemic using data from published and unpublished H1N1pdm seroepidemiological studies. Primary aggregate H1N1pdm serologic data from each study were stratified in standardized age groups and evaluated based on when sera were collected in relation to national or subnational peak H1N1pdm activity. Seropositivity was assessed using well‐described and standardized hemagglutination inhibition (HI titers ≥32 or ≥40) and microneutralization (MN ≥ 40) laboratory assays. The prevalence of cross‐reactive antibodies to the H1N1pdm virus was estimated for studies using sera collected prior to the start of the pandemic (between 2004 and April 2009); H1N1pdm cumulative incidence was estimated for studies in which collected both pre‐ and post‐pandemic sera; and H1N1pdm seropositivity was calculated from studies with post‐pandemic sera only (collected between December 2009–June 2010). Data from 27 published/unpublished studies from 19 countries/administrative regions – Australia, Canada, China, Finland, France, Germany, Hong Kong SAR, India, Iran, Italy, Japan, Netherlands, New Zealand, Norway, Reunion Island, Singapore, United Kingdom, United States, and Vietnam – were eligible for inclusion. The overall age‐standardized pre‐pandemic prevalence of cross‐reactive antibodies was 5% (95%CI 3–7%) and varied significantly by age with the highest rates among persons ≥65 years old (14% 95%CI 8–24%). Overall age‐standardized H1N1pdm cumulative incidence was 24% (95%CI 20–27%) and varied significantly by age with the highest in children 5–19 (47% 95%CI 39–55%) and 0–4 years old (36% 95%CI 30–43%). Our results offer unique insight into the global impact of the H1N1 pandemic and highlight the need for standardization of seroepidemiological studies and for their inclusion in pre‐pandemic preparedness plans. Our results taken together with recent global pandemic respiratory‐associated mortality estimates suggest that the case fatality ratio of the pandemic virus was approximately 0·02%.
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影响因子：
3.7
作者：
Chen, Mark I.;Barr, Ian G.;Leo, Yee-Sin
通讯作者：
Leo, Yee-Sin
DOI：
10.1056/nejmoa0905498
发表时间：
2009-12-31
期刊：
The New England journal of medicine
影响因子：
--
作者：
Cauchemez S;Donnelly CA;Reed C;Ghani AC;Fraser C;Kent CK;Finelli L;Ferguson NM
通讯作者：
Ferguson NM
影响因子：
14.2
作者：
Delangue, J.;Salez, N.;de Lamballerie, X.
通讯作者：
de Lamballerie, X.
影响因子：
4.4
作者：
Burmaa, Alexanderyn;Tsatsral, Sosorbaramyn;Nymadawa, Pagbajabyn
通讯作者：
Nymadawa, Pagbajabyn
影响因子：
5.4
作者：
Allwinn, Regina;Geiler, Janina;Doerr, H. W.
通讯作者：
Doerr, H. W.