Minimally Invasive Biospecimen Collection for Exposome Research in Children's Health.
Minimally Invasive Biospecimen Collection for Exposome Research in Children's Health.
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DOI：
10.1007/s40572-020-00277-2
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发表时间：
2020-09
影响因子：
7.9
通讯作者：
Niedzwiecki MM
中科院分区：
文献类型：
--
作者：
Petrick LM;Arora M;Niedzwiecki MM
低容量生物采样和新型生物标志物基质的出现为儿童采样提供了无创或微创方法。这些新技术与质谱技术的进步相结合，提供了对低浓度暴露的高灵敏度，可靠的测量，促进了非靶向代谢组学在儿童问题研究中的应用。在这里，我们回顾了替代生物基质（干燥毛细血管血、间质液、唾液、牙齿和头发）的新兴采样技术，并强调了这些采样器最近在推动基于人群的暴露研究中的发现方面的应用。生物取样和生物标志物技术显示出直接测量关键发展时期接触的潜力。虽然唾液是最传统的生物基质，但每种技术都有关键的优点和缺点。例如，头发和牙齿提供了对过去暴露的回顾性分析，干燥的毛细血管血提供了全身暴露的定量测量，与传统的静脉血测量相比更容易。重要的是，所有技术都可以或有可能在家中使用，从而增加儿童生物采样的便利性和父母的支持。本文介绍了新兴的样本采集技术，承诺为儿童的麻烦的研究。虽然在代谢组学中的应用仍然有限，但这些新的基质有望促进纵向代谢组学研究，以发现影响儿童健康的关键暴露和易感性窗口。
The advent of low-volume biosampling and novel biomarker matrices offers non- or minimally-invasive approaches to sampling in children. These new technologies, combined with advancements in mass spectrometry that provide high-sensitivity, robust measurements of low-concentration exposures, facilitate the application of untargeted metabolomics in children’s exposome research. Here, we review emerging sampling technologies for alternative biomatrices—dried capillary blood, interstitial fluid, saliva, teeth, and hair—and highlight recent applications of these samplers to drive discovery in population-based exposure research. Biosampling and biomarker technologies demonstrate potential to directly measure exposures during key developmental time periods. While saliva is the most traditional of the reported biomatrices, each technology has key advantages and disadvantages. For example, hair and teeth provide retrospective analysis of past exposures, and dried capillary blood provides quantitative measurements of systemic exposures that can be more readily compared to traditional venous blood measurements. Importantly, all technologies can or have the potential to be used at home, increasing the convenience and parental support for children’s biosampling. This review describes emerging sample collection technologies that hold promise for children’s exposome studies. While applications in metabolomics are still limited, these novel matrices are poised to facilitate longitudinal exposome studies to discover key exposures and windows of susceptibility affecting children’s health.
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影响因子：
6.2
作者：
De Kesel, Pieter M. M.;Lambert, Willy E.;Stove, Christophe P.
通讯作者：
Stove, Christophe P.
DOI：
10.1016/j.jpba.2017.03.037
发表时间：
2017-06-05
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3.6
作者：
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通讯作者：
Wishart, David S.
影响因子：
11.8
作者：
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通讯作者：
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