Invasive Candidiasis: Update and Current Challenges in the Management of This Mycosis in South America.
Invasive Candidiasis: Update and Current Challenges in the Management of This Mycosis in South America.
复制标题
侵袭性念珠菌病：南美治疗这种真菌病的最新进展和当前挑战。
DOI：
10.3390/antibiotics11070877
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发表时间：
2022-06-30
影响因子：
4.8
通讯作者：
Elena Sotomayor, Claudia
中科院分区：
文献类型：
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作者：
Oscar Riera, Fernando;Pablo Caeiro, Juan;Carla Angiolini, Sofia;Vigezzi, Cecilia;Rodriguez, Emilse;Alejandra Icely, Paula;Elena Sotomayor, Claudia
侵袭性念珠菌病包括念珠菌血流感染和深层念珠菌病可成为一个持久的健康问题。这些感染是由念珠菌引起的，发病率和死亡率很高。世界各地的物种分布、获得诊断、治疗和死亡率各不相同。南美洲的死亡率很高（30-70%），白色念珠菌是该地区最流行的菌种。然而，已经观察到全球流行病学向非白色念珠菌物种的转变。在这一组中，最常被检测到的物种是C. parapsilosis，其次是C. tropical，其次是C. glabrata，其速度较慢，除了新出现的C. auris外，还增加了对几种药物的耐药性。本文综述了念珠菌病发病机制的相关方面，如真菌侵袭机制、免疫反应、基因缺陷对宿主易感性的影响等。我们还讨论了南美洲治疗的相关方面和未来的挑战。
Invasive candidiasis encompassing Candida bloodstream infections and deep-seated candidiasis can become a persistent health problem. These infections are caused by Candida species and have high morbidity and mortality rates. Species distribution, access to diagnosis, treatment and mortality are different around the world. The mortality rate is high in South America (30–70%), and Candida albicans is the most prevalent species in this region. However, a global epidemiological shift to non-albicans species has been observed. In this group, C. parapsilosis is the species most frequently detected, followed by C. tropicalis, and at a slower rate, C. glabrata, which has also increased, in addition to the emerging C. auris, resistance to several drugs. This article summarizes relevant aspects of candidemia pathogenesis, such as the mechanisms of fungal invasion, immune response, and the impact of genetic defects that increase host susceptibility to developing the infection. We also discuss relevant aspects of treatment and future challenges in South America.
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DOI：
10.3390/jof3020024
发表时间：
2017-05-17
期刊：
Journal of fungi (Basel, Switzerland)
影响因子：
--
作者：
da Matta DA;Souza ACR;Colombo AL
通讯作者：
Colombo AL
影响因子：
11.3
作者：
d'Enfert C;Kaune AK;Alaban LR;Chakraborty S;Cole N;Delavy M;Kosmala D;Marsaux B;Fróis-Martins R;Morelli M;Rosati D;Valentine M;Xie Z;Emritloll Y;Warn PA;Bequet F;Bougnoux ME;Bornes S;Gresnigt MS;Hube B;Jacobsen ID;Legrand M;Leibundgut-Landmann S;Manichanh C;Munro CA;Netea MG;Queiroz K;Roget K;Thomas V;Thoral C;Van den Abbeele P;Walker AW;Brown AJP
通讯作者：
Brown AJP
2020年4月至7月，印度危害病毒病毒病患者的多药念珠菌感染。
影响因子：
11.8
作者：
Chowdhary A;Tarai B;Singh A;Sharma A
通讯作者：
Sharma A
影响因子：
4.6
作者：
Berrio, Indira;Maldonado, Natalia;Robledo, Jaime
通讯作者：
Robledo, Jaime
DOI：
10.3390/jof3040057
发表时间：
2017-10-18
期刊：
Journal of fungi (Basel, Switzerland)
影响因子：
--
作者：
Bongomin F;Gago S;Oladele RO;Denning DW
通讯作者：
Denning DW