Characterization of short- and long-term mechanical sensitisation following surgical tail amputation in pigs.
Characterization of short- and long-term mechanical sensitisation following surgical tail amputation in pigs.
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DOI：
10.1038/s41598-017-05404-y
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发表时间：
2017-07-06
影响因子：
4.6
通讯作者：
Sandercock DA
中科院分区：
文献类型：
--
作者：
Di Giminiani P;Edwards SA;Malcolm EM;Leach MC;Herskin MS;Sandercock DA
商业猪经常以预防性饲养程序（对接）或异常行为（咬尾）的形式暴露于断尾。虽然组织和神经损伤是人类和啮齿动物模型中疼痛超敏反应的充分描述的原因，但没有关于猪尾部损伤诱导的局部疼痛敏感性变化的信息。为了确定致敏的时间分布，将猪暴露于手术尾部切除，并在急性（术后1周）和长期（术后8周或16周）恢复期测量机械伤害性阈值（MNT）。通过比较三种不同的尾部切除治疗（完整、“短尾”、“长尾”），评价了截肢程度对MNT的影响。手术后一周MNTs的显著减少表明急性致敏的发生。在手术后两个月或四个月，在尾部切除的猪中也观察到长期超敏反应。猪的尾部截肢似乎引起外周机械敏感性的急性和持续变化，这类似于人类和其他物种中报告的神经性疼痛的特征，并提供了关于遭受这种类型损伤的动物福利的新信息。
Commercial pigs are frequently exposed to tail mutilations in the form of preventive husbandry procedures (tail docking) or as a result of abnormal behaviour (tail biting). Although tissue and nerve injuries are well-described causes of pain hypersensitivity in humans and in rodent animal models, there is no information on the changes in local pain sensitivity induced by tail injuries in pigs. To determine the temporal profile of sensitisation, pigs were exposed to surgical tail resections and mechanical nociceptive thresholds (MNT) were measured in the acute (one week post-operatively) and in the long-term (either eight or sixteen weeks post-surgery) phase of recovery. The influence of the degree of amputation on MNTs was also evaluated by comparing three different tail-resection treatments (intact, ‘short tail’, ‘long tail’). A significant reduction in MNTs one week following surgery suggests the occurrence of acute sensitisation. Long-term hypersensitivity was also observed in tail-resected pigs at either two or four months following surgery. Tail amputation in pigs appears to evoke acute and sustained changes in peripheral mechanical sensitivity, which resemble features of neuropathic pain reported in humans and other species and provides new information on implications for the welfare of animals subjected to this type of injury.
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影响因子：
3.6
作者：
Di Giminiani, P.;Petersen, L. J.;Herskin, M. S.
通讯作者：
Herskin, M. S.
在完整的猪尾部的机械伤害性阈值表征手持压力施加测量设备。
影响因子：
2.9
作者：
Di Giminiani P;Sandercock DA;Malcolm EM;Leach MC;Herskin MS;Edwards SA
通讯作者：
Edwards SA
影响因子：
2.4
作者：
Herskin, M. S.;Di Giminiani, P.;Thodberg, K.
通讯作者：
Thodberg, K.
影响因子：
2.7
作者：
Hsu E;Cohen SP
通讯作者：
Cohen SP
DOI：
10.1098/rspb.1967.0002
发表时间：
1967-01-01
期刊：
PROCEEDINGS OF THE ROYAL SOCIETY SERIES B-BIOLOGICAL SCIENCES
影响因子：
--
作者：
DICKERSON, JW;DOBBING, J
通讯作者：
DOBBING, J