Application of a handheld Pressure Application Measurement device for the characterisation of mechanical nociceptive thresholds in intact pig tails.
Application of a handheld Pressure Application Measurement device for the characterisation of mechanical nociceptive thresholds in intact pig tails.
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在完整的猪尾部的机械伤害性阈值表征手持压力施加测量设备。
DOI：
10.1016/j.physbeh.2016.07.006
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发表时间：
2016-10-15
影响因子：
2.9
通讯作者：
Edwards SA
中科院分区：
文献类型：
--
作者：
Di Giminiani P;Sandercock DA;Malcolm EM;Leach MC;Herskin MS;Edwards SA
在动物和人类中，伤害阈值的评估被用于评估组织损伤可能引起的敏感性变化。它在完整猪尾巴上的应用可能是一种评估尾巴损伤（如断尾或咬尾）引起的伤害阈值变化的合适方法。压力应用测量（PAM）装置首次在猪的尾巴上使用，以确定方法的可靠性，并提供与四个不同年龄组（9、17、24和32周）相关的机械伤害感受阈值（MNT）的新数据，并与目标区域与动物身体的接近程度有关。我们记录了总体上可接受的个体内信度水平，CV平均值在30.1到32.6%之间。在所有年龄组中，在1区（近端）记录的第一次MNT测量值显著高于随后两次（P < 0.05）。在尾部区域2和3（更远）没有观察到这种情况。年龄对伤害感觉的平均阈值有显著影响（P < 0.05），年龄越大，阈值越高。此外，尾端与体的距离显著影响（P < 0.05）， 9、17和24周龄猪尾端MNT较高。机械伤害感受阈值与动物年龄/体型呈显著正相关（P < 0.05）。据我们所知，还没有其他研究使用PAM装置或其他方法在不同年龄/体型的猪的完整尾巴上获得机械伤害阈值。用PAM装置获得的数据的可靠性支持其用于测量猪尾巴的机械伤害性阈值。该方法可能适用于评估断尾咬尾损伤后尾残端MNTs的变化。本文首次对猪尾的机械伤害知觉阈值进行了量化。PAM装置允许确定猪的解剖和年龄特异性阈值。提出了一个评估猪疼痛状况的平台。
The assessment of nociceptive thresholds is employed in animals and humans to evaluate changes in sensitivity potentially arising from tissue damage. Its application on the intact pig tail might represent a suitable method to assess changes in nociceptive thresholds arising from tail injury, such as tail docking or tail biting. The Pressure Application Measurement (PAM) device is used here for the first time on the tail of pigs to determine the reliability of the methods and to provide novel data on mechanical nociceptive thresholds (MNT) associated with four different age groups (9, 17, 24 and 32 weeks) and with proximity of the target region to the body of the animal. We recorded an overall acceptable level of intra-individual reliability, with mean values of CV ranging between 30.1 and 32.6%. Across all age groups, the first single measurement of MNT recorded at region 1 (proximal) was significantly higher (P < 0.05) than the following two. This was not observed at tail regions 2 and 3 (more distal). Age had a significant effect (P < 0.05) on the mean thresholds of nociception with increasing age corresponding to higher thresholds. Furthermore, a significant effect of proximity of tail region to the body was observed (P < 0.05), with MNT being higher in the proximal tail region in pigs of 9, 17 and 24 weeks of age. There was also a significant positive correlation (P < 0.05) between mechanical nociceptive thresholds and age/body size of the animals. To the best of our knowledge, no other investigation of tail nociceptive thresholds has been performed with the PAM device or alternative methods to obtain mechanical nociceptive thresholds in intact tails of pigs of different age/body size. The reliability of the data obtained with the PAM device support its use in the measurement of mechanical nociceptive threshold in pig tails. This methodological approach is possibly suitable for assessing changes in tail stump MNTs after tail injury caused by tail docking and biting. Mechanical nociceptive thresholds were quantified for the first time in pig tails. The PAM device allowed determining anatomical and age-specific thresholds in pigs. A platform for the assessment of painful conditions in pigs is proposed.
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影响因子：
1.4
作者：
Hirschfeld, Gerrit;Zernikow, Boris;Blankenburg, Markus
通讯作者：
Blankenburg, Markus
影响因子：
2.9
作者：
Clouard, Caroline;Loison, Florence;Val-Laillet, David
通讯作者：
Val-Laillet, David
影响因子：
1.1
作者：
Colditz, I. G.;Paull, D. R.;Lee, C.
通讯作者：
Lee, C.
影响因子：
3.6
作者：
Di Giminiani, P.;Petersen, L. J.;Herskin, M. S.
通讯作者：
Herskin, M. S.
影响因子：
7.4
作者：
Lautenbacher, S;Kunz, M;Arendt-Nielsen, L
通讯作者：
Arendt-Nielsen, L