Influence of white matter anisotropic conductivity on EEG source localization: comparison to fMRI in human primary visual cortex.
Influence of white matter anisotropic conductivity on EEG source localization: comparison to fMRI in human primary visual cortex.
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DOI：
10.1016/j.clinph.2009.09.007
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发表时间：
2009-12
期刊：
影响因子：
--
通讯作者：
He B
中科院分区：
文献类型：
--
作者：
Lee WH;Liu Z;Mueller BA;Lim K;He B
本研究的目的是通过实验研究脑白质电导率的各向异性对脑电信号源定位的影响。在相同的视觉刺激下记录了三名受试者的视觉诱发电位（VEP）和功能磁共振成像数据。采用有限元法求解各向异性和各向同性头部模型的脑电图正演问题，并进行单偶极子源定位，以定位N75 VEP分量下的源。各向同性和各向异性头部模型在V1区域N75偶极子位置的平均距离为0 ~ 6.22±2.83 mm。各向异性模型（7.49±1.35 ~ 15.70±8.60 mm）与各向同性模型（7.65±1.30 ~ 15.31±9.18 mm）相比，局部偶极子位置与fMRI V1激活中心的距离略小。利用视觉刺激获得的实验数据，结合真实WM各向异性电导率分布的各向异性模型并不能显著提高初级视觉皮层EEG偶极子定位的准确性。本研究首次尝试使用人体实验方法来评估脑电信号各向异性对脑电图源分析的影响。
The goal of this study was to experimentally investigate the influence of the anisotropy of white matter (WM) conductivity on EEG source localization. Visual evoked potentials (VEP) and fMRI data were recorded from three human subjects presented with identical visual stimuli. A finite element method was used to solve the EEG forward problems based on both anisotropic and isotropic head models, and single-dipole source localization was subsequently performed to localize the source underlying the N75 VEP component. The averaged distances of the localized N75 dipole locations in V1 between the isotropic and anisotropic head models ranged from 0 to 6.22 ± 2.83 mm. The distances between the localized dipole positions and the centers of the fMRI V1 activations were slightly smaller when using an anisotropic model (7.49 ± 1.35 to 15.70 ± 8.60 mm) than when using an isotropic model (7.65 ± 1.30 to 15.31 ± 9.18 mm). Anisotropic models incorporating realistic WM anisotropic conductivity distributions do not substantially improve the accuracy of EEG dipole localization in the primary visual cortex using experimental data obtained using visual stimulation. The present study represents the first attempt using a human experimental approach to assess the effects of WM anisotropy on EEG source analysis.
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