Column-based cortical depth analysis of the diffusion anisotropy and radiality in submillimeter whole-brain diffusion tensor imaging of the human cortical gray matter in vivo.
Column-based cortical depth analysis of the diffusion anisotropy and radiality in submillimeter whole-brain diffusion tensor imaging of the human cortical gray matter in vivo.
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DOI：
10.1016/j.neuroimage.2023.119993
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发表时间：
2023-04-15
期刊：
影响因子：
5.7
通讯作者：
Truong, Trong-Kha
中科院分区：
文献类型：
--
作者：
Ma, Yixin;Bruce, Iain P.;Yeh, Chun-Hung;Petrella, Jeffrey R.;Song, Allen W.;Truong, Trong-Kha
关键词：
高分辨率扩散张量成像(DTI)可以无创地探测活体皮质灰质的微结构。在这项研究中，使用高效的多波段多激发回波平面成像序列采集了健康受试者的0.9 mm各向同性全脑DTI数据。然后，通过对径向皮质柱的分数各向异性(FA)和径向指数(RI)采样的柱基分析，定量分析了FA和RI对整个大脑的皮质深度、皮质区域、皮质曲率和皮质厚度的依赖关系，这在以前的研究中没有被同时和系统地研究过。结果显示，除中央后回未见FA峰值和RI降低外，大部分皮质深度的FA和RI与皮质深度的关系具有特征性，局部FA最大值和最小值(或两个拐点)和单个RI最大值。这些结果在同一受试者和不同受试者的重复扫描中是一致的。它们还依赖于皮质曲率和皮质厚度，因为随着皮质厚度的增加，FA和RI的特征峰在岸边比在脑回顶部或在脑沟底部更明显。这种方法可以帮助描述在活体中沿着皮质深度和整个大脑的微观结构的变化，潜在地为神经疾病提供定量的生物标记物。
High-resolution diffusion tensor imaging (DTI) can noninvasively probe the microstructure of cortical gray matter in vivo. In this study, 0.9-mm isotropic whole-brain DTI data were acquired in healthy subjects with an efficient multi-band multi-shot echo-planar imaging sequence. A column-based analysis that samples the fractional anisotropy (FA) and radiality index (RI) along radially oriented cortical columns was then performed to quantitatively analyze the FA and RI dependence on the cortical depth, cortical region, cortical curvature, and cortical thickness across the whole brain, which has not been simultaneously and systematically investigated in previous studies. The results showed characteristic FA and RI vs. cortical depth profiles, with an FA local maximum and minimum (or two inflection points) and a single RI maximum at intermediate cortical depths in most cortical regions, except for the postcentral gyrus where no FA peaks and a lower RI were observed. These results were consistent between repeated scans from the same subjects and across different subjects. They were also dependent on the cortical curvature and cortical thickness in that the characteristic FA and RI peaks were more pronounced i) at the banks than at the crown of gyri or at the fundus of sulci and ii) as the cortical thickness increases. This methodology can help characterize variations in microstructure along the cortical depth and across the whole brain in vivo, potentially providing quantitative biomarkers for neurological disorders.
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DOI：
10.1006/jmrb.1994.1037
发表时间：
1994-03-01
期刊：
JOURNAL OF MAGNETIC RESONANCE SERIES B
影响因子：
--
作者：
BASSER, PJ;MATTIELLO, J;LEBIHAN, D
通讯作者：
LEBIHAN, D
影响因子：
3.3
作者：
Kellner, Elias;Dhital, Bibek;Reisert, Marco
通讯作者：
Reisert, Marco
影响因子：
5.7
作者：
Chen, Nan-kuei;Guidon, Arnaud;Chang, Hing-Chiu;Song, Allen W.
通讯作者：
Song, Allen W.
影响因子：
5.7
作者：
Dai, Erpeng;Liu, Simin;Guo, Hua
通讯作者：
Guo, Hua
影响因子：
5.7
作者：
Gulban OF;De Martino F;Vu AT;Yacoub E;Uğurbil K;Lenglet C
通讯作者：
Lenglet C