Alterations of plasma lysophosphatidylcholine species in obesity and weight loss.
Alterations of plasma lysophosphatidylcholine species in obesity and weight loss.
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DOI：
10.1371/journal.pone.0111348
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发表时间：
2014
期刊：
影响因子：
3.7
通讯作者：
Schmitz G
中科院分区：
文献类型：
--
作者：
Heimerl S;Fischer M;Baessler A;Liebisch G;Sigruener A;Wallner S;Schmitz G
肥胖和代谢综合征的相关疾病是工业化国家的主要健康问题。脂质类和脂质种类的代谢改变可能显著参与这些代谢超负荷疾病。然而，对这种综合征中的特定脂质种类知之甚少，现有数据相互矛盾。在这项研究中，我们量化的血浆脂质种类的电喷雾电离串联质谱（ESI-MS/MS）在肥胖受试者之前和之后3个月的体重减轻以及在对照组。减肥前肥胖者与对照者的比较显示，肥胖者的溶血磷脂酰胆碱（LPC）浓度显著降低。在观察期间，体重减轻组的LPC浓度未显著增加。LPC种类的分析显示，大多数种类的肥胖和C-反应蛋白（CRP）和体重指数（BMI）呈负相关。将体重减轻前后的BMI比值与总LPC和单个LPC物种的比值相关联，发现LPC比值与BMI比值呈显著负相关。我们的研究结果有助于LPC在肥胖和相关慢性炎症中的作用的矛盾讨论，强烈支持文献中现有的数据，这些数据显示肥胖患者血浆中LPC种类减少，并在这些受试者中具有潜在的抗炎作用。
Obesity and related diseases of the metabolic syndrome contribute to the major health problems in industrialized countries. Alterations in the metabolism of lipid classes and lipid species may significantly be involved in these metabolic overload diseases. However, little is known about specific lipid species in this syndrome and existing data are contradictive. In this study, we quantified plasma lipid species by electrospray ionization tandem mass spectrometry (ESI-MS/MS) in obese subjects before and after 3 month weight loss as well as in a control group. The comparison of obese subjects with control subjects before weight loss revealed significantly lower lysophosphatidylcholine (LPC) concentrations in obesity. LPC concentrations did not significantly increase during the observed period in the weight loss group. Analysis of LPC species revealed a decrease of most species in obesity and negative correlations with C-reactive protein (CRP) and body mass index (BMI). Correlating BMI ratio before and after weight loss with the ratio of total LPC and individual LPC species revealed significant negative relationships of LPC ratios with BMI ratio. Our findings contribute to the contradictive discussion of the role of LPC in obesity and related chronic inflammation strongly supporting pre-existing data in the literature that show a decrease of LPC species in plasma of obese and a potentially anti-inflammatory role in these subjects.
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影响因子：
5.1
作者：
Kita, T;Kume, N;Yokode, M
通讯作者：
Yokode, M
异常葡萄糖代谢受试者的饮食诱导的体重减轻（Genobin研究）中的三酰基甘油脂肪酸组成。
影响因子：
3.7
作者：
Schwab U;Seppänen-Laakso T;Yetukuri L;Agren J;Kolehmainen M;Laaksonen DE;Ruskeepää AL;Gylling H;Uusitupa M;Oresic M;GENOBIN Study Group
通讯作者：
GENOBIN Study Group
影响因子：
3.7
作者：
Meikle PJ;Wong G;Barlow CK;Weir JM;Greeve MA;MacIntosh GL;Almasy L;Comuzzie AG;Mahaney MC;Kowalczyk A;Haviv I;Grantham N;Magliano DJ;Jowett JB;Zimmet P;Curran JE;Blangero J;Shaw J
通讯作者：
Shaw J
影响因子：
3.7
作者：
Barber MN;Risis S;Yang C;Meikle PJ;Staples M;Febbraio MA;Bruce CR
通讯作者：
Bruce CR
影响因子：
7.1
作者：
Nestel, Paul John;Straznicky, Nora;Meikle, Peter John
通讯作者：
Meikle, Peter John