Triacylglycerol fatty acid composition in diet-induced weight loss in subjects with abnormal glucose metabolism--the GENOBIN study.
Triacylglycerol fatty acid composition in diet-induced weight loss in subjects with abnormal glucose metabolism--the GENOBIN study.
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异常葡萄糖代谢受试者的饮食诱导的体重减轻（Genobin研究）中的三酰基甘油脂肪酸组成。
DOI：
10.1371/journal.pone.0002630
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发表时间：
2008-07-09
期刊：
影响因子：
3.7
通讯作者：
GENOBIN Study Group
中科院分区：
文献类型：
--
作者：
Schwab U;Seppänen-Laakso T;Yetukuri L;Agren J;Kolehmainen M;Laaksonen DE;Ruskeepää AL;Gylling H;Uusitupa M;Oresic M;GENOBIN Study Group
在分子水平上，体重减轻对不同血脂亚类的影响尚不清楚。本研究的目的是检查饮食诱导的体重减轻是否会导致代谢综合征特征受试者在33周干预中扩展血脂谱（脂质组）的变化。使用基于质谱法的脂质组学和脂肪酸分析，分析体重减轻组中9名受试者和对照组中10名受试者的血浆样品。体重减轻组体重下降7.8±2.9%（p<0.01）。大部分血清甘油三酯和磷脂酰胆碱降低。三酰甘油的减少主要影响饱和短链脂肪酸。含三酰甘油的饱和短链脂肪酸的减少与胰岛素敏感性的增加相关。然而，包括花生四烯酸和二十二碳六烯酸在内的几种长链脂肪酸的水平不受体重减轻的影响。其他已知与肥胖相关的脂质水平，如鞘脂和溶血磷脂酰胆碱，并没有因体重减轻而改变。饮食诱导的体重减轻导致糖代谢异常受试者的总体脂质谱发生显著变化。观察到的变化可能影响这些受试者的胰岛素敏感性和葡萄糖代谢。ClinicalTrials.gov www.example.com
The effect of weight loss on different plasma lipid subclasses at the molecular level is unknown. The aim of this study was to examine whether a diet-induced weight reduction result in changes in the extended plasma lipid profiles (lipidome) in subjects with features of metabolic syndrome in a 33-week intervention. Plasma samples of 9 subjects in the weight reduction group and 10 subjects in the control group were analyzed using mass spectrometry based lipidomic and fatty acid analyses. Body weight decreased in the weight reduction group by 7.8±2.9% (p<0.01). Most of the serum triacylglycerols and phosphatidylcholines were reduced. The decrease in triacylglycerols affected predominantly the saturated short chain fatty acids. This decrease of saturated short chain fatty acid containing triacylglycerols correlated with the increase of insulin sensitivity. However, levels of several longer chain fatty acids, including arachidonic and docosahexanoic acid, were not affected by weight loss. Levels of other lipids known to be associated with obesity such as sphingolipids and lysophosphatidylcholines were not altered by weight reduction. Diet-induced weight loss caused significant changes in global lipid profiles in subjects with abnormal glucose metabolism. The observed changes may affect insulin sensitivity and glucose metabolism in these subjects. ClinicalTrials.gov NCT00621205
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影响因子：
5.4
作者：
Boston, Ray C;Stefanovski, Darko;Bergman, Richard N
通讯作者：
Bergman, Richard N
影响因子：
5
作者：
Nelson, J;Jiang, XC;Shea, S
通讯作者：
Shea, S
DOI：
10.1016/j.jasms.2005.04.017
发表时间：
2005-09-01
影响因子：
3.2
作者：
McAnoy, AM;Wu, CC;Murphy, RC
通讯作者：
Murphy, RC
影响因子：
7.4
作者：
Ekroos, K;Chernushevich, IV;Shevchenko, A
通讯作者：
Shevchenko, A
影响因子：
7.7
作者：
RABINI, RA;GALASSI, R;MAZZANTI, L
通讯作者：
MAZZANTI, L