Genetic variants in IL1A and IL1B contribute to the susceptibility to 2009 pandemic H1N1 influenza A virus.
Genetic variants in IL1A and IL1B contribute to the susceptibility to 2009 pandemic H1N1 influenza A virus.
复制标题
IL1A 和 IL1B 的基因变异导致对 2009 年大流行的 H1N1 甲型流感病毒的易感性。
DOI：
10.1186/1471-2172-14-37
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发表时间：
2013-08-08
期刊：
影响因子：
3
通讯作者：
Zeng G
中科院分区：
文献类型：
--
作者：
Liu Y;Li S;Zhang G;Nie G;Meng Z;Mao D;Chen C;Chen X;Zhou B;Zeng G
Host genetic variations may contribute to disease susceptibility of influenza. IL-1A and IL-1B are important inflammatory cytokines that mediate the inflammation and initiate the immune response against virus infection. In this study, we investigated the relationship between single-nucleotide polymorphisms (SNPs) of Interleukin-1A (IL-1A) and Interleukin-1B (IL-1B) and the susceptibility to 2009 pandemic A/H1N1 influenza (A(H1N1)pdm09). 167 patients whom were confirmed with A(H1N1)pdm09 and 192 healthy controls were included in this study. Four SNPs (rs1304037, rs16347, rs17561, rs2071373) in IL1A gene and three SNPs (rs1143623, rs3917345, rs1143627) in IL1B gene were genotyped by using matrix-assisted laser desorption/ionization time-of-flight (MALDI-TOF) mass spectrometry platform, and the associations of the genetic variants of IL-1 with susceptibility to A(H1N1)pdm09 were then assessed. The polymorphisms of rs17561 in IL1A gene and rs1143627 in IL1B gene were found to be associated with susceptibility to A(H1N1)pdm09 with P values of 0.003 (OR 2.08, 95% CI 1.27-3.41) and 0.002 (OR 1.62 , 95% CI 1.20-2.18), respectively. However, no significant difference in allelic frequency was observed for other SNPs between cases and controls. This study provides a new insight into pathogenesis of A(H1N1)pdm09, suggesting that genetic variants of IL-1A and IL-1B may exert a substantial impact on the susceptibility of A(H1N1)pdm09 virus infection.
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影响因子：
30.5
作者：
Acosta-Rodriguez, Eva V.;Napolitani, Giorgio;Sallusto, Federica
通讯作者：
Sallusto, Federica
影响因子：
3.6
作者：
Fierro, Nora A.;Escobedo-Melendez, Griselda;Panduro, Arturo
通讯作者：
Panduro, Arturo
影响因子：
30.8
作者：
de Bakker, PIW;Yelensky, R;Altshuler, D
通讯作者：
Altshuler, D
影响因子：
3.8
作者：
Berger, P;McConnell, JP;Duff, GW
通讯作者：
Duff, GW
影响因子：
3.7
作者：
Morales-García G;Falfán-Valencia R;García-Ramírez RA;Camarena Á;Ramirez-Venegas A;Castillejos-López M;Pérez-Rodríguez M;González-Bonilla C;Grajales-Muñíz C;Borja-Aburto V;Mejía-Aranguré JM
通讯作者：
Mejía-Aranguré JM