Circulating leukocyte telomere length and risk of overall and aggressive prostate cancer.
Circulating leukocyte telomere length and risk of overall and aggressive prostate cancer.
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DOI：
10.1038/bjc.2014.640
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发表时间：
2015-02-17
影响因子：
8.8
通讯作者：
Platz, E. A.
中科院分区：
文献类型：
--
作者：
Julin, B.;Shui, I.;Heaphy, C. M.;Joshu, C. E.;Meeker, A. K.;Giovannucci, E.;De Vivo, I.;Platz, E. A.
最近的大规模前瞻性研究表明，长端粒与癌症风险增加有关，这与传统观点相反。为了进一步阐明白细胞端粒长度（LTL）和前列腺癌之间的关联，并评估与LTL和前列腺癌相关的遗传变异性，我们进行了一项巢式病例对照研究（922例病例和935例对照）。参与者在1993-1995年提供血液，并随访至2004年8月（前列腺癌发病率）或2013年2月28日（致命或致命前列腺癌）。通过定量PCR测量相对LTL，并计算为端粒重复拷贝数与单个基因（36 B4）拷贝数的比值（T/S）。使用TaqMan OpenArray SNP基因分型平台进行基因分型。使用逻辑回归来估计所有前列腺癌和由Gleason分级、分期和致死率（转移或死亡）定义的亚型的比值比（OR）和95%置信区间（CI）。我们观察到每个s.d. LTL和所有（多变量校正OR 1.11，95% CI：1.01-1.22）、低级别（OR 1.13，95% CI：1.01-1.27）和局部（OR 1.12，95% CI：1.01-1.24）前列腺癌增加。其他亚型的相关性相似，但未达到统计学显著性。在亚组分析中，与无家族史的男性相比，有家族史的男性与高级别和晚期（OR=2.04，95%CI 1.00-4.17; P相互作用=0.06）或致死性疾病（OR=2.37，95%CI 1.19-4.72; P相互作用=0.01）的相关性更强。SNP的次要等位基因rs7726159，先前已被证明与LTL呈正相关，在多重检验校正后，与所有前列腺癌风险呈负相关（P=0.0005）。在这项前瞻性研究中，较长的LTL与前列腺癌的高风险适度相关。有家族病史的男性中更侵袭性癌症的更强关联需要在更大规模的研究中证实。
Recent large-scale prospective studies suggest that long telomeres are associated with an increase cancer risk, counter to conventional wisdom. To further clarify the association between leukocyte telomere length (LTL) and prostate cancer, and assess genetic variability in relation to both LTL and prostate cancer, we performed a nested case–control study (922 cases and 935 controls). The participants provided blood in 1993–1995 and were followed through August 2004 (prostate cancer incidence) or until 28 February 2013 (lethal or fatal prostate cancer). Relative LTL was measured by quantitative PCR and was calculated as the ratio of telomere repeat copy number to a single gene (36B4) copy number (T/S). Genotyping was performed using the TaqMan OpenArray SNP Genotyping Platform. Logistic regression was used to estimate odds ratios (ORs) and 95% confidence intervals (CIs) of all prostate cancer and subtypes defined by Gleason grade, stage and lethality (metastasis or death). We observed a positive association between each s.d. increase in LTL and all (multivariable-adjusted OR 1.11, 95% CI: 1.01–1.22), low-grade (OR 1.13, 95% CI:1.01–1.27), and localised (OR 1.12, 95% CI:1.01–1.24) prostate cancer. Associations for other subtypes were similar, but did not reach statistical significance. In subgroup analyses, associations for high grade and advanced stage (OR=2.04, 95% CI 1.00–4.17; Pinteraction=0.06) or lethal disease (OR=2.37, 95% CI 1.19–4.72; Pinteraction=0.01) were stronger in men with a family history of the disease compared with those without. The minor allele of SNP, rs7726159, which has previously been shown to be positively associated with LTL, showed an inverse association with all prostate cancer risk after correction for multiple testing (P=0.0005). In this prospective study, longer LTL was modestly associated with higher risk of prostate cancer. A stronger association for more aggressive cancer in men with a family history of the disease needs to be confirmed in larger studies.
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影响因子：
6.4
作者：
Lynch SM;Major JM;Cawthon R;Weinstein SJ;Virtamo J;Lan Q;Rothman N;Albanes D;Stolzenberg-Solomon RZ
通讯作者：
Stolzenberg-Solomon RZ
多阶段全基因组关联研究确定了七个前列腺癌易感位点
影响因子：
30.8
作者：
通讯作者：
--
影响因子：
8
作者：
Ducray, C;Pommier, JP;Sabatier, L
通讯作者：
Sabatier, L
DOI：
10.1158/1055-9965.epi-13-0409
发表时间：
2013-11
期刊：
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
影响因子：
--
作者：
Cunningham JM;Johnson RA;Litzelman K;Skinner HG;Seo S;Engelman CD;Vanderboom RJ;Kimmel GW;Gangnon RE;Riegert-Johnson DL;Baron JA;Potter JD;Haile R;Buchanan DD;Jenkins MA;Rider DN;Thibodeau SN;Petersen GM;Boardman LA
通讯作者：
Boardman LA
影响因子：
11.2
作者：
Pooley KA;Sandhu MS;Tyrer J;Shah M;Driver KE;Luben RN;Bingham SA;Ponder BA;Pharoah PD;Khaw KT;Easton DF;Dunning AM
通讯作者：
Dunning AM